Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy

Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy

As a promising modality for cancer therapy, photodynamic therapy (PDT) still acquired limited success in clinical nowadays due to the extremely serious hypoxia and immunosuppression tumor microenvironment. To ameliorate such a situation, we rationally designed and prepared cascade two-stage re-oxyge...

Full description

Bibliographic Details
Main Authors: Zaigang Zhou, Jiashe Chen, Yu Liu, Chunjuan Zheng, Wenjuan Luo, Lele Chen, Shen Zhou, Zhiming Li, Jianliang Shen
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Photodynamic immunotherapy
Sorafenib
Hypoxia
Tumor vessel normalization
Mitochondrial oxidative phosphorylation
Programmed death ligand-1
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352200329X

Internet

http://www.sciencedirect.com/science/article/pii/S221138352200329X

Similar Items