Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy

Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy

As a promising modality for cancer therapy, photodynamic therapy (PDT) still acquired limited success in clinical nowadays due to the extremely serious hypoxia and immunosuppression tumor microenvironment. To ameliorate such a situation, we rationally designed and prepared cascade two-stage re-oxyge...

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Detalles Bibliográficos
Autores principales: Zaigang Zhou, Jiashe Chen, Yu Liu, Chunjuan Zheng, Wenjuan Luo, Lele Chen, Shen Zhou, Zhiming Li, Jianliang Shen
Formato: Artículo
Lenguaje:English
Publicado: Elsevier 2022-11-01
Colección:Acta Pharmaceutica Sinica B
Materias:
Photodynamic immunotherapy
Sorafenib
Hypoxia
Tumor vessel normalization
Mitochondrial oxidative phosphorylation
Programmed death ligand-1
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S221138352200329X

Internet

http://www.sciencedirect.com/science/article/pii/S221138352200329X

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