A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain
Pain management plays an essential role in medical care. Previous studies showed that pain is a dynamic process involving multiple mechanisms, which inspired the concept of multimodal analgesia. Therefore, a drug delivery system loaded with a single analgesic may be insufficient for pain control. In...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522011649 |
| _version_ | 1811175467015733248 |
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| author | Yumiao He Fengrun Sun Mohan Li Tianjiao Ji Yehong Fang Gang Tan Chao Ma Yuguang Huang |
| author_facet | Yumiao He Fengrun Sun Mohan Li Tianjiao Ji Yehong Fang Gang Tan Chao Ma Yuguang Huang |
| author_sort | Yumiao He |
| collection | DOAJ |
| description | Pain management plays an essential role in medical care. Previous studies showed that pain is a dynamic process involving multiple mechanisms, which inspired the concept of multimodal analgesia. Therefore, a drug delivery system loaded with a single analgesic may be insufficient for pain control. In this study, an implantable thermogel/electrospun fiber (Gel/Fiber) system loaded with bupivacaine hydrochloride (BUP-HCl) and acetaminophen (APAP) was synthesized. In the composite, BUP-HCl was preferentially released from the hydrophilic thermogel to relieve nociceptive pain, followed by the release of APAP in a more sustained manner from hydrophobic fibers to reduce the inflammatory reaction. Pain behavioral study and activation assay of spinal glial cells in the chronic constriction injury (CCI) model demonstrated the superior analgesic efficacy and chronic pain prevention property of the Gel/Fiber system. Furthermore, the composite exhibited satisfactory biocompatibility, as shown by histological and pharmacokinetic analysis. These results indicate that the successful sequential BUP-HCl/APAP release by a Gel/Fiber system alleviates chronic pain with good biocompatibility.Our study may pave the way for the future application of extended-delivery systems. |
| first_indexed | 2024-04-10T19:36:23Z |
| format | Article |
| id | doaj.art-3a3505c5e29640ff9f811b736cc67c08 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T19:36:23Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-3a3505c5e29640ff9f811b736cc67c082023-01-30T04:12:29ZengElsevierMaterials & Design0264-12752023-01-01225111541A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic painYumiao He0Fengrun Sun1Mohan Li2Tianjiao Ji3Yehong Fang4Gang Tan5Chao Ma6Yuguang Huang7Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China; Joint Laboratory of Anesthesia and Pain, Peking Union Medical College, Beijing 100730, ChinaDepartment of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, ChinaDepartment of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China; Joint Laboratory of Anesthesia and Pain, Peking Union Medical College, Beijing 100730, ChinaNational Center for Nanoscience and Technology, Beijing 100190, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China; Joint Laboratory of Anesthesia and Pain, Peking Union Medical College, Beijing 100730, China; Corresponding authors at: Dongdansantiao No.9, Dongcheng District, Beijing 100005, China (Chao Ma), Shuaifuyuan No.1, Dongcheng District, Beijing 100730, China (Yuguang Huang).Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China; Joint Laboratory of Anesthesia and Pain, Peking Union Medical College, Beijing 100730, China; Corresponding authors at: Dongdansantiao No.9, Dongcheng District, Beijing 100005, China (Chao Ma), Shuaifuyuan No.1, Dongcheng District, Beijing 100730, China (Yuguang Huang).Pain management plays an essential role in medical care. Previous studies showed that pain is a dynamic process involving multiple mechanisms, which inspired the concept of multimodal analgesia. Therefore, a drug delivery system loaded with a single analgesic may be insufficient for pain control. In this study, an implantable thermogel/electrospun fiber (Gel/Fiber) system loaded with bupivacaine hydrochloride (BUP-HCl) and acetaminophen (APAP) was synthesized. In the composite, BUP-HCl was preferentially released from the hydrophilic thermogel to relieve nociceptive pain, followed by the release of APAP in a more sustained manner from hydrophobic fibers to reduce the inflammatory reaction. Pain behavioral study and activation assay of spinal glial cells in the chronic constriction injury (CCI) model demonstrated the superior analgesic efficacy and chronic pain prevention property of the Gel/Fiber system. Furthermore, the composite exhibited satisfactory biocompatibility, as shown by histological and pharmacokinetic analysis. These results indicate that the successful sequential BUP-HCl/APAP release by a Gel/Fiber system alleviates chronic pain with good biocompatibility.Our study may pave the way for the future application of extended-delivery systems.http://www.sciencedirect.com/science/article/pii/S0264127522011649ThermogelElectrospun fibersMultimodal analgesiaSequential releaseChronic pain |
| spellingShingle | Yumiao He Fengrun Sun Mohan Li Tianjiao Ji Yehong Fang Gang Tan Chao Ma Yuguang Huang A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain Materials & Design Thermogel Electrospun fibers Multimodal analgesia Sequential release Chronic pain |
| title | A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain |
| title_full | A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain |
| title_fullStr | A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain |
| title_full_unstemmed | A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain |
| title_short | A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain |
| title_sort | gel fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain |
| topic | Thermogel Electrospun fibers Multimodal analgesia Sequential release Chronic pain |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522011649 |
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