Ganglion Cell Layer Thinning in Alzheimer’s Disease
The main advantages of optical retinal imaging may allow researchers to achieve deeper analysis of retinal ganglion cells (GC) in vivo using optical coherence tomography (OCT). Using this device to elucidate the impact of Alzheimer’s disease (AD) on retinal health with the aim to identify a new AD b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1010-660X/56/10/553 |
| _version_ | 1797710220891258880 |
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| author | Alicia López-de-Eguileta Andrea Cerveró Ainara Ruiz de Sabando Pascual Sánchez-Juan Alfonso Casado |
| author_facet | Alicia López-de-Eguileta Andrea Cerveró Ainara Ruiz de Sabando Pascual Sánchez-Juan Alfonso Casado |
| author_sort | Alicia López-de-Eguileta |
| collection | DOAJ |
| description | The main advantages of optical retinal imaging may allow researchers to achieve deeper analysis of retinal ganglion cells (GC) in vivo using optical coherence tomography (OCT). Using this device to elucidate the impact of Alzheimer’s disease (AD) on retinal health with the aim to identify a new AD biomarker, a large amount of studies has analyzed GC in different stages of the disease. Our review highlights recent knowledge into measuring retinal morphology in AD making distinctive between whether those studies included patients with clinical dementia stage or also mild cognitive impairment (MCI), which selection criteria were applied to diagnosed patients included, and which device of OCT was employed. Despite several differences, previous works found a significant thinning of GC layer in patients with AD and MCI. In the long term, an important future direction is to achieve a specific ocular biomarker with enough sensitivity to reveal preclinical AD disorder and to monitor progression. |
| first_indexed | 2024-03-12T06:48:06Z |
| format | Article |
| id | doaj.art-3a3684b8729b48dba4652b3bf2faf67a |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T06:48:06Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-3a3684b8729b48dba4652b3bf2faf67a2023-09-03T00:26:39ZengMDPI AGMedicina1010-660X2020-10-015655355310.3390/medicina56100553Ganglion Cell Layer Thinning in Alzheimer’s DiseaseAlicia López-de-Eguileta0Andrea Cerveró1Ainara Ruiz de Sabando2Pascual Sánchez-Juan3Alfonso Casado4Department of Ophthalmology, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Institute for Research ‘Marqués de Valdecilla’ (IDIVAL), 39008 Santander, SpainDepartment of Ophthalmology, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Institute for Research ‘Marqués de Valdecilla’ (IDIVAL), 39008 Santander, SpainGenetic deoartment, Navarrabiomed, 31008 Pamplona, SpainNeurology Department and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Institute for Research ‘Marqués de Valdecilla’ (IDIVAL), 39008 Santander, SpainDepartment of Ophthalmology, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Institute for Research ‘Marqués de Valdecilla’ (IDIVAL), 39008 Santander, SpainThe main advantages of optical retinal imaging may allow researchers to achieve deeper analysis of retinal ganglion cells (GC) in vivo using optical coherence tomography (OCT). Using this device to elucidate the impact of Alzheimer’s disease (AD) on retinal health with the aim to identify a new AD biomarker, a large amount of studies has analyzed GC in different stages of the disease. Our review highlights recent knowledge into measuring retinal morphology in AD making distinctive between whether those studies included patients with clinical dementia stage or also mild cognitive impairment (MCI), which selection criteria were applied to diagnosed patients included, and which device of OCT was employed. Despite several differences, previous works found a significant thinning of GC layer in patients with AD and MCI. In the long term, an important future direction is to achieve a specific ocular biomarker with enough sensitivity to reveal preclinical AD disorder and to monitor progression.https://www.mdpi.com/1010-660X/56/10/553ganglion cellsoptical coherence tomographyAlzheimer’s diseasemild cognitive impairment |
| spellingShingle | Alicia López-de-Eguileta Andrea Cerveró Ainara Ruiz de Sabando Pascual Sánchez-Juan Alfonso Casado Ganglion Cell Layer Thinning in Alzheimer’s Disease Medicina ganglion cells optical coherence tomography Alzheimer’s disease mild cognitive impairment |
| title | Ganglion Cell Layer Thinning in Alzheimer’s Disease |
| title_full | Ganglion Cell Layer Thinning in Alzheimer’s Disease |
| title_fullStr | Ganglion Cell Layer Thinning in Alzheimer’s Disease |
| title_full_unstemmed | Ganglion Cell Layer Thinning in Alzheimer’s Disease |
| title_short | Ganglion Cell Layer Thinning in Alzheimer’s Disease |
| title_sort | ganglion cell layer thinning in alzheimer s disease |
| topic | ganglion cells optical coherence tomography Alzheimer’s disease mild cognitive impairment |
| url | https://www.mdpi.com/1010-660X/56/10/553 |
| work_keys_str_mv | AT alicialopezdeeguileta ganglioncelllayerthinninginalzheimersdisease AT andreacervero ganglioncelllayerthinninginalzheimersdisease AT ainararuizdesabando ganglioncelllayerthinninginalzheimersdisease AT pascualsanchezjuan ganglioncelllayerthinninginalzheimersdisease AT alfonsocasado ganglioncelllayerthinninginalzheimersdisease |