A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived?
Hydrophilic interaction liquid chromatography (HILIC) today is a well-known and largely applied technique to analyse polar compounds such as pharmaceuticals, metabolites, proteins, peptides, amino acids, oligonucleotides, and carbohydrates. Due to the large number of stationary phases employed for H...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Separations |
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| Online Access: | https://www.mdpi.com/2297-8739/10/1/22 |
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| author | Maria A. Guarducci Andrea Fochetti Alessia Ciogli Giulia Mazzoccanti |
| author_facet | Maria A. Guarducci Andrea Fochetti Alessia Ciogli Giulia Mazzoccanti |
| author_sort | Maria A. Guarducci |
| collection | DOAJ |
| description | Hydrophilic interaction liquid chromatography (HILIC) today is a well-known and largely applied technique to analyse polar compounds such as pharmaceuticals, metabolites, proteins, peptides, amino acids, oligonucleotides, and carbohydrates. Due to the large number of stationary phases employed for HILIC applications, this review aims to help the reader in choosing a proper stationary phase, which often represents the critical point for the success of a separation. A great offer is present for achiral applications in contrast to the chiral phases developed for HILIC enantioseparations. In the last case, up-to-date solutions are presented. |
| first_indexed | 2024-03-09T11:14:45Z |
| format | Article |
| id | doaj.art-3a3968e4c68b40e3b209489991527d9e |
| institution | Directory Open Access Journal |
| issn | 2297-8739 |
| language | English |
| last_indexed | 2024-03-09T11:14:45Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Separations |
| spelling | doaj.art-3a3968e4c68b40e3b209489991527d9e2023-12-01T00:32:18ZengMDPI AGSeparations2297-87392022-12-011012210.3390/separations10010022A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived?Maria A. Guarducci0Andrea Fochetti1Alessia Ciogli2Giulia Mazzoccanti3Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, ItalyDipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, ItalyDipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, ItalyDipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “La Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, ItalyHydrophilic interaction liquid chromatography (HILIC) today is a well-known and largely applied technique to analyse polar compounds such as pharmaceuticals, metabolites, proteins, peptides, amino acids, oligonucleotides, and carbohydrates. Due to the large number of stationary phases employed for HILIC applications, this review aims to help the reader in choosing a proper stationary phase, which often represents the critical point for the success of a separation. A great offer is present for achiral applications in contrast to the chiral phases developed for HILIC enantioseparations. In the last case, up-to-date solutions are presented.https://www.mdpi.com/2297-8739/10/1/22HILICstationary phasesachiral applicationsenantioseparations |
| spellingShingle | Maria A. Guarducci Andrea Fochetti Alessia Ciogli Giulia Mazzoccanti A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived? Separations HILIC stationary phases achiral applications enantioseparations |
| title | A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived? |
| title_full | A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived? |
| title_fullStr | A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived? |
| title_full_unstemmed | A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived? |
| title_short | A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived? |
| title_sort | compendium of the principal stationary phases used in hydrophilic interaction chromatography where have we arrived |
| topic | HILIC stationary phases achiral applications enantioseparations |
| url | https://www.mdpi.com/2297-8739/10/1/22 |
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