The role of the TNF receptors and apoptosis inducing ligands in tumor growth
Tumor necrosis factor (TNF) superfamily receptors and TNF apoptosis inducing ligands play an important role in the realization of TNF function and control tumor growth. The TNF-related pathways are controlled by endoplasmic reticulum stress signaling, which has a crucial role in the control of cell...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2016-10-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2016/11/Minchenko_5_16.pdf |
| _version_ | 1827775456730939392 |
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| author | O. H. Minchenko1 D. O. Tsymbal1 D. O. Minchenko1,2, О. O. Ratushna1 |
| author_facet | O. H. Minchenko1 D. O. Tsymbal1 D. O. Minchenko1,2, О. O. Ratushna1 |
| author_sort | O. H. Minchenko1 |
| collection | DOAJ |
| description | Tumor necrosis factor (TNF) superfamily receptors and TNF apoptosis inducing ligands play an important role in the realization of TNF function and control tumor growth. The TNF-related pathways are controlled by endoplasmic reticulum stress signaling, which has a crucial role in the control of cell proliferation and tumor growth. Furthermore, the inhibition of IRE1 (inositol requiring enzyme-1), which is a central mediator of endoplasmic reticulum stress sand mainly responsible for cell proliferation and apoptosis, leads to suppression of tumor growth through specific changes in the expression of genes encoding transcription factors, tumor suppressors, angiogenesis and apoptosis related proteins, including TNF superfamily receptors and TNF apoptosis inducing ligands. Therefore, changes in the expression level of TNF-related genes encoding TNF superfamily receptors and apoptosis inducing ligands possibly reflect metabolic reprogramming of cancer cells upon inhibition of IRE1-mediated endoplasmic reticulum stress signaling and correlate with suppression of glioma cell proliferation. |
| first_indexed | 2024-03-11T13:49:58Z |
| format | Article |
| id | doaj.art-3a3b071dfd1b42ad98b2d5584f8067a5 |
| institution | Directory Open Access Journal |
| issn | 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T13:49:58Z |
| publishDate | 2016-10-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-3a3b071dfd1b42ad98b2d5584f8067a52023-11-02T09:08:35ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2413-50032016-10-01885183710.15407/ubj88.05.018The role of the TNF receptors and apoptosis inducing ligands in tumor growthO. H. Minchenko10D. O. Tsymbal11D. O. Minchenko1,2,2 О. O. Ratushna13Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;2Bohomolets National Medical University, Kyiv, UkrainPalladin Institute of Biochemistry, NationalAcademy of Sciences of Ukraine, Kyiv ; Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;Tumor necrosis factor (TNF) superfamily receptors and TNF apoptosis inducing ligands play an important role in the realization of TNF function and control tumor growth. The TNF-related pathways are controlled by endoplasmic reticulum stress signaling, which has a crucial role in the control of cell proliferation and tumor growth. Furthermore, the inhibition of IRE1 (inositol requiring enzyme-1), which is a central mediator of endoplasmic reticulum stress sand mainly responsible for cell proliferation and apoptosis, leads to suppression of tumor growth through specific changes in the expression of genes encoding transcription factors, tumor suppressors, angiogenesis and apoptosis related proteins, including TNF superfamily receptors and TNF apoptosis inducing ligands. Therefore, changes in the expression level of TNF-related genes encoding TNF superfamily receptors and apoptosis inducing ligands possibly reflect metabolic reprogramming of cancer cells upon inhibition of IRE1-mediated endoplasmic reticulum stress signaling and correlate with suppression of glioma cell proliferation.http://ukrbiochemjournal.org/wp-content/uploads/2016/11/Minchenko_5_16.pdfdecoy receptorsglioma cellsIRE1 inhibitionTNF superfamily receptorsTRAIL |
| spellingShingle | O. H. Minchenko1 D. O. Tsymbal1 D. O. Minchenko1,2, О. O. Ratushna1 The role of the TNF receptors and apoptosis inducing ligands in tumor growth The Ukrainian Biochemical Journal decoy receptors glioma cells IRE1 inhibition TNF superfamily receptors TRAIL |
| title | The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
| title_full | The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
| title_fullStr | The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
| title_full_unstemmed | The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
| title_short | The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
| title_sort | role of the tnf receptors and apoptosis inducing ligands in tumor growth |
| topic | decoy receptors glioma cells IRE1 inhibition TNF superfamily receptors TRAIL |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2016/11/Minchenko_5_16.pdf |
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