Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation
Stroke is a leading cause of mortality and disability worldwide, with most survivors reporting dysfunctions of motor, sensation, deglutition, cognition, emotion, and speech, etc. Repetitive transcranial magnetic stimulation (rTMS), one of noninvasive brain stimulation (NIBS) techniques, is able to m...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197422/full |
| _version_ | 1797822523914584064 |
|---|---|
| author | Rongjun Sheng Changchun Chen Huan Chen Peipei Yu |
| author_facet | Rongjun Sheng Changchun Chen Huan Chen Peipei Yu |
| author_sort | Rongjun Sheng |
| collection | DOAJ |
| description | Stroke is a leading cause of mortality and disability worldwide, with most survivors reporting dysfunctions of motor, sensation, deglutition, cognition, emotion, and speech, etc. Repetitive transcranial magnetic stimulation (rTMS), one of noninvasive brain stimulation (NIBS) techniques, is able to modulate neural excitability of brain regions and has been utilized in neurological and psychiatric diseases. Moreover, a large number of studies have shown that the rTMS presents positive effects on function recovery of stroke patients. In this review, we would like to summarized the clinical benefits of rTMS for stroke rehabilitation, including improvements of motor impairment, dysphagia, depression, cognitive function, and central post-stroke pain. In addition, this review will also discuss the molecular and cellular mechanisms underlying rTMS-mediated stroke rehabilitation, especially immune regulatory mechanisms, such as regulation of immune cells and inflammatory cytokines. Moreover, the neuroimaging technique as an important tool in rTMS-mediated stroke rehabilitation has been discussed, to better understanding the mechanisms underlying the effects of rTMS. Finally, the current challenges and future prospects of rTMS-mediated stroke rehabilitation are also elucidated with the intention to accelerate its widespread clinical application. |
| first_indexed | 2024-03-13T10:10:21Z |
| format | Article |
| id | doaj.art-3a3c50f0f6004ba195578eb3e39d7f42 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T10:10:21Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3a3c50f0f6004ba195578eb3e39d7f422023-05-22T04:33:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11974221197422Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammationRongjun Sheng0Changchun Chen1Huan Chen2Peipei Yu3Department of Radiology, The First People’s Hospital of Linping District, Hangzhou, ChinaDepartment of Radiology, The People’s Hospital of Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, ChinaDepartment of Radiology, The People’s Hospital of Longyou, Quzhou, ChinaDepartment of Radiology, Sanmen People’s Hospital, Taizhou, ChinaStroke is a leading cause of mortality and disability worldwide, with most survivors reporting dysfunctions of motor, sensation, deglutition, cognition, emotion, and speech, etc. Repetitive transcranial magnetic stimulation (rTMS), one of noninvasive brain stimulation (NIBS) techniques, is able to modulate neural excitability of brain regions and has been utilized in neurological and psychiatric diseases. Moreover, a large number of studies have shown that the rTMS presents positive effects on function recovery of stroke patients. In this review, we would like to summarized the clinical benefits of rTMS for stroke rehabilitation, including improvements of motor impairment, dysphagia, depression, cognitive function, and central post-stroke pain. In addition, this review will also discuss the molecular and cellular mechanisms underlying rTMS-mediated stroke rehabilitation, especially immune regulatory mechanisms, such as regulation of immune cells and inflammatory cytokines. Moreover, the neuroimaging technique as an important tool in rTMS-mediated stroke rehabilitation has been discussed, to better understanding the mechanisms underlying the effects of rTMS. Finally, the current challenges and future prospects of rTMS-mediated stroke rehabilitation are also elucidated with the intention to accelerate its widespread clinical application.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197422/fulltranscranial magnetic stimulationstrokerehabilitationneuroinflammationmicroglianeurotransmitter |
| spellingShingle | Rongjun Sheng Changchun Chen Huan Chen Peipei Yu Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation Frontiers in Immunology transcranial magnetic stimulation stroke rehabilitation neuroinflammation microglia neurotransmitter |
| title | Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation |
| title_full | Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation |
| title_fullStr | Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation |
| title_full_unstemmed | Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation |
| title_short | Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation |
| title_sort | repetitive transcranial magnetic stimulation for stroke rehabilitation insights into the molecular and cellular mechanisms of neuroinflammation |
| topic | transcranial magnetic stimulation stroke rehabilitation neuroinflammation microglia neurotransmitter |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197422/full |
| work_keys_str_mv | AT rongjunsheng repetitivetranscranialmagneticstimulationforstrokerehabilitationinsightsintothemolecularandcellularmechanismsofneuroinflammation AT changchunchen repetitivetranscranialmagneticstimulationforstrokerehabilitationinsightsintothemolecularandcellularmechanismsofneuroinflammation AT huanchen repetitivetranscranialmagneticstimulationforstrokerehabilitationinsightsintothemolecularandcellularmechanismsofneuroinflammation AT peipeiyu repetitivetranscranialmagneticstimulationforstrokerehabilitationinsightsintothemolecularandcellularmechanismsofneuroinflammation |