Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
Abstract Background Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding....
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | BMC Medical Research Methodology |
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| Online Access: | http://link.springer.com/article/10.1186/s12874-017-0402-9 |
| _version_ | 1828517030108594176 |
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| author | Mónica Ballesteros Nadia Montero Antonio López-Pousa Gerard Urrútia Ivan Solà Gabriel Rada Hector Pardo-Hernandez Xavier Bonfill |
| author_facet | Mónica Ballesteros Nadia Montero Antonio López-Pousa Gerard Urrútia Ivan Solà Gabriel Rada Hector Pardo-Hernandez Xavier Bonfill |
| author_sort | Mónica Ballesteros |
| collection | DOAJ |
| description | Abstract Background Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding. Our objectives are to identify, describe and organise the current available evidence for GIST through an evidence mapping approach. Methods We followed the methodology of Global Evidence Mapping (GEM). We searched Pubmed, EMBASE, The Cochrane Library and Epistemonikos in order to identify systematic reviews (SRs) with or without meta-analyses published between 1990 and March 2016. Two authors assessed eligibility and extracted data. Methodological quality of the included systematic reviews was assessed using AMSTAR. We organised the results according to identified PICO questions and presented the evidence map in tables and a bubble plot. Results A total of 17 SRs met eligibility criteria. These reviews included 66 individual studies, of which three quarters were either observational or uncontrolled clinical trials. Overall, the quality of the included SRs was moderate or high. In total, we extracted 14 PICO questions from them and the corresponding results mostly favoured the intervention arm. Conclusions The most common type of study used to evaluate therapeutic interventions in GIST sarcomas has been non-experimental studies. However, the majority of the interventions are reported as beneficial or probably beneficial by the respective authors of SRs. The evidence mapping is a useful and reliable methodology to identify and present the existing evidence about therapeutic interventions. |
| first_indexed | 2024-12-11T18:36:00Z |
| format | Article |
| id | doaj.art-3a3d96b07bd546479c80b469ba1b1090 |
| institution | Directory Open Access Journal |
| issn | 1471-2288 |
| language | English |
| last_indexed | 2024-12-11T18:36:00Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Research Methodology |
| spelling | doaj.art-3a3d96b07bd546479c80b469ba1b10902022-12-22T00:54:46ZengBMCBMC Medical Research Methodology1471-22882017-09-0117111410.1186/s12874-017-0402-9Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)Mónica Ballesteros0Nadia Montero1Antonio López-Pousa2Gerard Urrútia3Ivan Solà4Gabriel Rada5Hector Pardo-Hernandez6Xavier Bonfill7Iberoamerican Cochrane CentreIberoamerican Cochrane CentreOncología Médica y Unidad de Curas Paliativas, Hospital de la Santa Creu i Sant PauIberoamerican Cochrane Centre - Sant Pau Biomedical Research Institute, (IIB Sant Pau), CIBER Epidemiología y Salud Pública (CIBERESP), Universitat Autònoma de BarcelonaIberoamerican Cochrane Centre - Sant Pau Biomedical Research Institute, (IIB Sant Pau), CIBER Epidemiología y Salud Pública (CIBERESP), Universitat Autònoma de BarcelonaPrograma de Salud Basada en la Evidencia, Facultad de Medicina, Pontificia Universidad Católica de ChileIberoamerican Cochrane Centre - Sant Pau Biomedical Research Institute, (IIB Sant Pau), CIBER Epidemiología y Salud Pública (CIBERESP), Universitat Autònoma de BarcelonaIberoamerican Cochrane Centre - Sant Pau Biomedical Research Institute, (IIB Sant Pau), CIBER Epidemiología y Salud Pública (CIBERESP), Universitat Autònoma de BarcelonaAbstract Background Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding. Our objectives are to identify, describe and organise the current available evidence for GIST through an evidence mapping approach. Methods We followed the methodology of Global Evidence Mapping (GEM). We searched Pubmed, EMBASE, The Cochrane Library and Epistemonikos in order to identify systematic reviews (SRs) with or without meta-analyses published between 1990 and March 2016. Two authors assessed eligibility and extracted data. Methodological quality of the included systematic reviews was assessed using AMSTAR. We organised the results according to identified PICO questions and presented the evidence map in tables and a bubble plot. Results A total of 17 SRs met eligibility criteria. These reviews included 66 individual studies, of which three quarters were either observational or uncontrolled clinical trials. Overall, the quality of the included SRs was moderate or high. In total, we extracted 14 PICO questions from them and the corresponding results mostly favoured the intervention arm. Conclusions The most common type of study used to evaluate therapeutic interventions in GIST sarcomas has been non-experimental studies. However, the majority of the interventions are reported as beneficial or probably beneficial by the respective authors of SRs. The evidence mapping is a useful and reliable methodology to identify and present the existing evidence about therapeutic interventions.http://link.springer.com/article/10.1186/s12874-017-0402-9GISTGastrointestinal Stromal TumoursEvidence mappingEvidence synthesisGlobal evidence mapping |
| spellingShingle | Mónica Ballesteros Nadia Montero Antonio López-Pousa Gerard Urrútia Ivan Solà Gabriel Rada Hector Pardo-Hernandez Xavier Bonfill Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST) BMC Medical Research Methodology GIST Gastrointestinal Stromal Tumours Evidence mapping Evidence synthesis Global evidence mapping |
| title | Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST) |
| title_full | Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST) |
| title_fullStr | Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST) |
| title_full_unstemmed | Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST) |
| title_short | Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST) |
| title_sort | evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors gist |
| topic | GIST Gastrointestinal Stromal Tumours Evidence mapping Evidence synthesis Global evidence mapping |
| url | http://link.springer.com/article/10.1186/s12874-017-0402-9 |
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