Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway

Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway

Aims: Acute liver failure (ALF) is a life-threatening disease characterized by abrupt and extensive hepatic necrosis and apoptosis, resulting in high mortality. The approved drug, N-acetylcysteine (NAC), is only effective for acetaminophen (APAP)-associated ALF at the early stage. Thus, we investiga...

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Main Authors: Lei Gu, Xin He, Yanqiu Zhang, Shenglan Li, Jie Tang, Ruixue Ma, Xinyi Yang, Hao Huang, Yu Peng, Yanyun Xie, Zhangzhe Peng, Jie Meng, Gaoyun Hu, Lijian Tao, Xiaowei Liu, Huixiang Yang
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Acute liver failure
Fluorofenidone
N-acetylcysteine
MKK4
JNK
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223006340

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