The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism
Following increased epidemiological studies indicating the relationship between diabetes and Alzheimer’s disease (AD), Type 2 diabetes has been reported to be a risk factor for the progress of AD pathology. Insulin resistance that develops in the brain, impairment in the insulin signal delivery syst...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2022-02-01
|
| Series: | Bezmiâlem Science |
| Subjects: | |
| Online Access: |
http://bezmialemscience.org/archives/archive-detail/article-preview/the-effect-of-type-2-diabetes-mellitus-on-the-deve/50748
|
| _version_ | 1797919018359717888 |
|---|---|
| author | Rabia DURAN Sümeyra PANCUR Fatemeh BAHADORİ |
| author_facet | Rabia DURAN Sümeyra PANCUR Fatemeh BAHADORİ |
| author_sort | Rabia DURAN |
| collection | DOAJ |
| description | Following increased epidemiological studies indicating the relationship between diabetes and Alzheimer’s disease (AD), Type 2 diabetes has been reported to be a risk factor for the progress of AD pathology. Insulin resistance that develops in the brain, impairment in the insulin signal delivery system and glucose metabolism have been shown among the most likely pathophysiological causes of AD. It has been reported that the increase in AD markers such as phospho tau and Aβ in the type 2 diabetes model of rats is associated with the decrease in the insulin receptor (IR) signaling and insulin-like growth factor-1 receptors (IGF-1R) ratio. Furthermore, intracellular components such as phospho-AKT (protein kinase B) and phospho-glycogen synthase kinase-3β (GSK3β), which are members of IR pathway, have been proved to be reduced in AD. Due to the common molecular mechanisms underlying the pathological development of Type 2 Diabetes and AD, treatment protocols indicated in diabetes have been used in the treatment of AD. |
| first_indexed | 2024-04-10T13:39:57Z |
| format | Article |
| id | doaj.art-3a3e2cdb9fbb48c5b3674ea9e065fcb8 |
| institution | Directory Open Access Journal |
| issn | 2148-2373 |
| language | English |
| last_indexed | 2024-04-10T13:39:57Z |
| publishDate | 2022-02-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Bezmiâlem Science |
| spelling | doaj.art-3a3e2cdb9fbb48c5b3674ea9e065fcb82023-02-15T16:11:14ZengGalenos Publishing HouseBezmiâlem Science2148-23732022-02-0110111412210.14235/bas.galenos.2020.449113049054The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular MechanismRabia DURAN0Sümeyra PANCUR1Fatemeh BAHADORİ2 Bezmialem Vakıf University Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, İstanbul, Turkey İstanbul University Faculty of Pharmacy, İstanbul, Turkey Bezmialem Vakıf University Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, İstanbul, Turkey Following increased epidemiological studies indicating the relationship between diabetes and Alzheimer’s disease (AD), Type 2 diabetes has been reported to be a risk factor for the progress of AD pathology. Insulin resistance that develops in the brain, impairment in the insulin signal delivery system and glucose metabolism have been shown among the most likely pathophysiological causes of AD. It has been reported that the increase in AD markers such as phospho tau and Aβ in the type 2 diabetes model of rats is associated with the decrease in the insulin receptor (IR) signaling and insulin-like growth factor-1 receptors (IGF-1R) ratio. Furthermore, intracellular components such as phospho-AKT (protein kinase B) and phospho-glycogen synthase kinase-3β (GSK3β), which are members of IR pathway, have been proved to be reduced in AD. Due to the common molecular mechanisms underlying the pathological development of Type 2 Diabetes and AD, treatment protocols indicated in diabetes have been used in the treatment of AD. http://bezmialemscience.org/archives/archive-detail/article-preview/the-effect-of-type-2-diabetes-mellitus-on-the-deve/50748 diabetesalzheimer’sirigf-1rp-aktgsk3βamyloid βtau |
| spellingShingle | Rabia DURAN Sümeyra PANCUR Fatemeh BAHADORİ The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism Bezmiâlem Science diabetes alzheimer’s ir igf-1r p-akt gsk3β amyloid β tau |
| title | The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism |
| title_full | The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism |
| title_fullStr | The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism |
| title_full_unstemmed | The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism |
| title_short | The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism |
| title_sort | effect of type 2 diabetes mellitus on the development of alzheimer s disease and its molecular mechanism |
| topic | diabetes alzheimer’s ir igf-1r p-akt gsk3β amyloid β tau |
| url |
http://bezmialemscience.org/archives/archive-detail/article-preview/the-effect-of-type-2-diabetes-mellitus-on-the-deve/50748
|
| work_keys_str_mv | AT rabiaduran theeffectoftype2diabetesmellitusonthedevelopmentofalzheimersdiseaseanditsmolecularmechanism AT sumeyrapancur theeffectoftype2diabetesmellitusonthedevelopmentofalzheimersdiseaseanditsmolecularmechanism AT fatemehbahadori theeffectoftype2diabetesmellitusonthedevelopmentofalzheimersdiseaseanditsmolecularmechanism AT rabiaduran effectoftype2diabetesmellitusonthedevelopmentofalzheimersdiseaseanditsmolecularmechanism AT sumeyrapancur effectoftype2diabetesmellitusonthedevelopmentofalzheimersdiseaseanditsmolecularmechanism AT fatemehbahadori effectoftype2diabetesmellitusonthedevelopmentofalzheimersdiseaseanditsmolecularmechanism |