The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca<sup>2+</sup> is not only an important messenger for cell proliferation, but it is also an indispensable signal fo...
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6667 |
| _version_ | 1797486419813335040 |
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| author | Linlin Zhang Jingyi Qi Xu Zhang Xiya Zhao Peng An Yongting Luo Junjie Luo |
| author_facet | Linlin Zhang Jingyi Qi Xu Zhang Xiya Zhao Peng An Yongting Luo Junjie Luo |
| author_sort | Linlin Zhang |
| collection | DOAJ |
| description | Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca<sup>2+</sup> is not only an important messenger for cell proliferation, but it is also an indispensable signal for cell death. Ca<sup>2+</sup> participates in and plays a crucial role in the energy metabolism, physiology, and pathology of mitochondria. Mitochondria control the uptake and release of Ca<sup>2+</sup> through channels/transporters, such as the mitochondrial calcium uniporter (MCU), and influence the concentration of Ca<sup>2+</sup> in both mitochondria and cytoplasm, thereby regulating cellular Ca<sup>2+</sup> homeostasis. Mitochondrial Ca<sup>2+</sup> transport-related processes are involved in important biological processes of tumor cells including proliferation, metabolism, and apoptosis. In particular, MCU and its regulatory proteins represent a new era in the study of MCU-mediated mitochondrial Ca<sup>2+</sup> homeostasis in tumors. Through an in-depth analysis of the close correlation between mitochondrial Ca<sup>2+</sup> and energy metabolism, autophagy, and apoptosis of tumor cells, we can provide a valuable reference for further understanding of how mitochondrial Ca<sup>2+</sup> regulation helps diagnosis and therapy. |
| first_indexed | 2024-03-09T23:33:58Z |
| format | Article |
| id | doaj.art-3a43d59d115d4a14bbd4a4ac272cdbff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:33:58Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3a43d59d115d4a14bbd4a4ac272cdbff2023-11-23T17:04:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312666710.3390/ijms23126667The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor CellsLinlin Zhang0Jingyi Qi1Xu Zhang2Xiya Zhao3Peng An4Yongting Luo5Junjie Luo6Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaMitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca<sup>2+</sup> is not only an important messenger for cell proliferation, but it is also an indispensable signal for cell death. Ca<sup>2+</sup> participates in and plays a crucial role in the energy metabolism, physiology, and pathology of mitochondria. Mitochondria control the uptake and release of Ca<sup>2+</sup> through channels/transporters, such as the mitochondrial calcium uniporter (MCU), and influence the concentration of Ca<sup>2+</sup> in both mitochondria and cytoplasm, thereby regulating cellular Ca<sup>2+</sup> homeostasis. Mitochondrial Ca<sup>2+</sup> transport-related processes are involved in important biological processes of tumor cells including proliferation, metabolism, and apoptosis. In particular, MCU and its regulatory proteins represent a new era in the study of MCU-mediated mitochondrial Ca<sup>2+</sup> homeostasis in tumors. Through an in-depth analysis of the close correlation between mitochondrial Ca<sup>2+</sup> and energy metabolism, autophagy, and apoptosis of tumor cells, we can provide a valuable reference for further understanding of how mitochondrial Ca<sup>2+</sup> regulation helps diagnosis and therapy.https://www.mdpi.com/1422-0067/23/12/6667mitochondrial calciumcalcium homeostasiscalcium regulationMCUtumor |
| spellingShingle | Linlin Zhang Jingyi Qi Xu Zhang Xiya Zhao Peng An Yongting Luo Junjie Luo The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells International Journal of Molecular Sciences mitochondrial calcium calcium homeostasis calcium regulation MCU tumor |
| title | The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells |
| title_full | The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells |
| title_fullStr | The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells |
| title_full_unstemmed | The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells |
| title_short | The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells |
| title_sort | regulatory roles of mitochondrial calcium and the mitochondrial calcium uniporter in tumor cells |
| topic | mitochondrial calcium calcium homeostasis calcium regulation MCU tumor |
| url | https://www.mdpi.com/1422-0067/23/12/6667 |
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