New Lignans from the Leaves and Stems of Kadsura philippinensis

Three novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 1–5 were determined by spectroscopic analyses, especially 2D...

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Main Authors: Chang-Hung Chou, Yao-Haur Kuo, Michael Y. Chiang, I-Wen Lo, Chia-Ching Liaw, Yuan-Bin Cheng, Yu-Chi Lin, Ya-Ching Shen
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/18/6/6573
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author Chang-Hung Chou
Yao-Haur Kuo
Michael Y. Chiang
I-Wen Lo
Chia-Ching Liaw
Yuan-Bin Cheng
Yu-Chi Lin
Ya-Ching Shen
author_facet Chang-Hung Chou
Yao-Haur Kuo
Michael Y. Chiang
I-Wen Lo
Chia-Ching Liaw
Yuan-Bin Cheng
Yu-Chi Lin
Ya-Ching Shen
author_sort Chang-Hung Chou
collection DOAJ
description Three novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 1–5 were determined by spectroscopic analyses, especially 2D NMR techniques. The structure of compound 5 was further confirmed by X-ray crystallographic analysis. Compounds 1 and 2 have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxoethylidene]}-pentano(2,3-dihydrobenzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton.
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spelling doaj.art-3a44a45ae18e4807be957d2d3a2286a72022-12-21T23:52:58ZengMDPI AGMolecules1420-30492013-06-011866573658310.3390/molecules18066573New Lignans from the Leaves and Stems of Kadsura philippinensisChang-Hung ChouYao-Haur KuoMichael Y. ChiangI-Wen LoChia-Ching LiawYuan-Bin ChengYu-Chi LinYa-Ching ShenThree novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 1–5 were determined by spectroscopic analyses, especially 2D NMR techniques. The structure of compound 5 was further confirmed by X-ray crystallographic analysis. Compounds 1 and 2 have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxoethylidene]}-pentano(2,3-dihydrobenzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton.http://www.mdpi.com/1420-3049/18/6/6573Kadsura philippinensistaiwankadsurinslignans
spellingShingle Chang-Hung Chou
Yao-Haur Kuo
Michael Y. Chiang
I-Wen Lo
Chia-Ching Liaw
Yuan-Bin Cheng
Yu-Chi Lin
Ya-Ching Shen
New Lignans from the Leaves and Stems of Kadsura philippinensis
Molecules
Kadsura philippinensis
taiwankadsurins
lignans
title New Lignans from the Leaves and Stems of Kadsura philippinensis
title_full New Lignans from the Leaves and Stems of Kadsura philippinensis
title_fullStr New Lignans from the Leaves and Stems of Kadsura philippinensis
title_full_unstemmed New Lignans from the Leaves and Stems of Kadsura philippinensis
title_short New Lignans from the Leaves and Stems of Kadsura philippinensis
title_sort new lignans from the leaves and stems of kadsura philippinensis
topic Kadsura philippinensis
taiwankadsurins
lignans
url http://www.mdpi.com/1420-3049/18/6/6573
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