AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo

AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo

Abstract Background Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and reducing ATP production to regulate cellular metabolism. Both the UCP2 and ROS are increased in cochleae in age-r...

Full description

Bibliographic Details
Main Authors: Chunli Zhao, Zijing Yang, Zhongrui Chen, Wenqi Liang, Shusheng Gong, Zhengde Du
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Molecular Medicine
Subjects:
UCP2
ARHL
IHC
AMPKα
Mitochondrion
Apoptosis
Online Access:https://doi.org/10.1186/s10020-022-00552-y

Similar Items

Similar Items