Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound
Enabling formulations are used by the pharmaceutical industry to help improve bioavailability of compounds with low solubility and permeability properties. Suspoemulsions are a combination strategy of using permeation enhancers in a lipid phase, with drug molecules incorporated as a solid nanosuspe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Huddersfield Press
2023-12-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/1408/galley/1037/view/ |
| Summary: | Enabling formulations are used by the pharmaceutical industry to help improve bioavailability of compounds with low solubility and permeability properties. Suspoemulsions are a combination strategy of using permeation enhancers in a lipid phase, with drug molecules incorporated as a solid nanosuspension in the aqueous phase to maximise oral exposure. Here, a suspoemulsion is created by bead milling a classical drug suspension to reach nano size range and combining with a lipid blend of Labrasol ALF and Capmul MCM. This formulation increased oral bioavailability from 5% to 24%. The exact mechanism of this improvement is hypothesised but would need further work to establish. |
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| ISSN: | 2058-8356 |