Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound
Enabling formulations are used by the pharmaceutical industry to help improve bioavailability of compounds with low solubility and permeability properties. Suspoemulsions are a combination strategy of using permeation enhancers in a lipid phase, with drug molecules incorporated as a solid nanosuspe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2023-12-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/1408/galley/1037/view/ |
| _version_ | 1797353867746213888 |
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| author | Darren Matthews Charlotte Carr Madhura Kale Dawn Bloomfield |
| author_facet | Darren Matthews Charlotte Carr Madhura Kale Dawn Bloomfield |
| author_sort | Darren Matthews |
| collection | DOAJ |
| description | Enabling formulations are used by the pharmaceutical industry to help improve bioavailability of compounds with low solubility and permeability properties. Suspoemulsions are a combination strategy of using permeation enhancers in a lipid phase, with drug molecules incorporated as a solid nanosuspension in the aqueous phase to maximise oral exposure. Here, a suspoemulsion is created by bead milling a classical drug suspension to reach nano size range and combining with a lipid blend of Labrasol ALF and Capmul MCM. This formulation increased oral bioavailability from 5% to 24%. The exact mechanism of this improvement is hypothesised but would need further work to establish. |
| first_indexed | 2024-03-08T13:37:12Z |
| format | Article |
| id | doaj.art-3a459323cdca459e8dad3ac69f077665 |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-08T13:37:12Z |
| publishDate | 2023-12-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-3a459323cdca459e8dad3ac69f0776652024-01-16T15:37:06ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562023-12-018210.5920/bjpharm.1408Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV CompoundDarren Matthews0Charlotte CarrMadhura KaleDawn BloomfieldCharles River LaboratoriesEnabling formulations are used by the pharmaceutical industry to help improve bioavailability of compounds with low solubility and permeability properties. Suspoemulsions are a combination strategy of using permeation enhancers in a lipid phase, with drug molecules incorporated as a solid nanosuspension in the aqueous phase to maximise oral exposure. Here, a suspoemulsion is created by bead milling a classical drug suspension to reach nano size range and combining with a lipid blend of Labrasol ALF and Capmul MCM. This formulation increased oral bioavailability from 5% to 24%. The exact mechanism of this improvement is hypothesised but would need further work to establish.https://www.bjpharm.org.uk/article/1408/galley/1037/view/nanosuspensionsuspoemulsionenabling formulationsdcs |
| spellingShingle | Darren Matthews Charlotte Carr Madhura Kale Dawn Bloomfield Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound British Journal of Pharmacy nanosuspension suspoemulsion enabling formulations dcs |
| title | Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound |
| title_full | Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound |
| title_fullStr | Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound |
| title_full_unstemmed | Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound |
| title_short | Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound |
| title_sort | use of a suspoemulsion to improve bioavailability of a dcs class iv compound |
| topic | nanosuspension suspoemulsion enabling formulations dcs |
| url | https://www.bjpharm.org.uk/article/1408/galley/1037/view/ |
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