Milk exosomes: beyond dietary microRNAs
Abstract Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line of research is slowed by a controversy whether the delivery and bioactivity of a s...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Genes & Nutrition |
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| Online Access: | http://link.springer.com/article/10.1186/s12263-017-0562-6 |
| _version_ | 1811293071325790208 |
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| author | Janos Zempleni |
| author_facet | Janos Zempleni |
| author_sort | Janos Zempleni |
| collection | DOAJ |
| description | Abstract Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line of research is slowed by a controversy whether the delivery and bioactivity of a single class of vesicle cargos, microRNAs, are real or not. This opinion paper argues that the evidence in support of the bioavailability of microRNAs encapsulated in dietary exosomes outweighs the evidence produced by scholars doubting that phenomenon is real. Importantly, this paper posits that the time is ripe to look beyond microRNA cargos and pursue innovative pathways through which dietary exosomes alter metabolism. Here, we highlight potentially fruitful lines of exploration. |
| first_indexed | 2024-04-13T04:55:57Z |
| format | Article |
| id | doaj.art-3a4b0b522811491fac4cf0086bd31426 |
| institution | Directory Open Access Journal |
| issn | 1555-8932 1865-3499 |
| language | English |
| last_indexed | 2024-04-13T04:55:57Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Genes & Nutrition |
| spelling | doaj.art-3a4b0b522811491fac4cf0086bd314262022-12-22T03:01:29ZengBMCGenes & Nutrition1555-89321865-34992017-06-011211410.1186/s12263-017-0562-6Milk exosomes: beyond dietary microRNAsJanos Zempleni0Department of Nutrition and Health Sciences, University of Nebraska-LincolnAbstract Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line of research is slowed by a controversy whether the delivery and bioactivity of a single class of vesicle cargos, microRNAs, are real or not. This opinion paper argues that the evidence in support of the bioavailability of microRNAs encapsulated in dietary exosomes outweighs the evidence produced by scholars doubting that phenomenon is real. Importantly, this paper posits that the time is ripe to look beyond microRNA cargos and pursue innovative pathways through which dietary exosomes alter metabolism. Here, we highlight potentially fruitful lines of exploration.http://link.springer.com/article/10.1186/s12263-017-0562-6ExosomesExtracellular vesiclesMilk |
| spellingShingle | Janos Zempleni Milk exosomes: beyond dietary microRNAs Genes & Nutrition Exosomes Extracellular vesicles Milk |
| title | Milk exosomes: beyond dietary microRNAs |
| title_full | Milk exosomes: beyond dietary microRNAs |
| title_fullStr | Milk exosomes: beyond dietary microRNAs |
| title_full_unstemmed | Milk exosomes: beyond dietary microRNAs |
| title_short | Milk exosomes: beyond dietary microRNAs |
| title_sort | milk exosomes beyond dietary micrornas |
| topic | Exosomes Extracellular vesicles Milk |
| url | http://link.springer.com/article/10.1186/s12263-017-0562-6 |
| work_keys_str_mv | AT janoszempleni milkexosomesbeyonddietarymicrornas |