ECDI‐fixed donor splenocytes prolong skin allograft survival by promoting M2 macrophage polarization and inducing regulatory T cells

ECDI‐fixed donor splenocytes prolong skin allograft survival by promoting M2 macrophage polarization and inducing regulatory T cells

Abstract Rejection is a common complication of allogeneic tissue transplantation. Fixation of splenocytes (SP) with 1‐ethyl‐3‐(3'‐dimethylaminopropyl)‐carbodiimide (ECDI) induces immune tolerance in recipients post‐transplantation; however, the mechanism underlying this effect remains unclear....

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Bibliographic Details
Main Authors: Bo Zhou, Yuan Zhang, Dongliang Zhang, Yun Zhang, Jiangang Xie, Xuexin Zhang, Jianke Ding, Yingjun Su, Shuzhong Guo, Ran Zhuang
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:FASEB BioAdvances
Subjects:
donor‐specific tolerance
ECDI‐SP
transplantation rejection
Online Access:https://doi.org/10.1096/fba.2019-00029

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