Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective Study
Purpose: Gastro-esophageal reflux disease (GERD) is prevalent and causes erosive esophagitis (EE) with varying degrees of severity (A to D according to the Los Angeles Classification). Adherence to medical therapy is crucial for treatment success. We compared adherence to treatment recommendations b...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/11/3196 |
| _version_ | 1797492814227963904 |
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| author | Amir Mari Wasef Na’amnih Aiman Gahshan Helal Saied Ahmad Tawfik Khoury Khitam Muhsen |
| author_facet | Amir Mari Wasef Na’amnih Aiman Gahshan Helal Saied Ahmad Tawfik Khoury Khitam Muhsen |
| author_sort | Amir Mari |
| collection | DOAJ |
| description | Purpose: Gastro-esophageal reflux disease (GERD) is prevalent and causes erosive esophagitis (EE) with varying degrees of severity (A to D according to the Los Angeles Classification). Adherence to medical therapy is crucial for treatment success. We compared adherence to treatment recommendations between patients with EE grades C/D and A/B. Methods: A follow-up study was conducted during 2019–2020 among GERD patients who underwent a diagnostic gastroscopy 1–4 years earlier. Telephone interviews were conducted with patients diagnosed with severe EE grades C/D (n = 99) and randomly selected patients with mild–moderate EE grades A/B (n = 50). Patients with grades A/B were classified as adherent if they took proton pump inhibitors (PPIs) for 2–3 months as recommended. Patients with grades C/D were classified as adherent if they took medications for a prolonged period (>6 months) and performed a follow-up endoscopy as recommended. Results: The mean age of the participants was 44.6 years (SD = 15.1). The mean duration of PPIs therapy in patients with EE grades A/B was 9.4 months (SD = 8.7). Fourteen (14.2%) patients with EE grades A/B were non-adherent to treatment, compared to 21 (40.8%) patients with EE grades of C/D: adjusted OR = 0.06; CI 95% 0.02–0.18, <i>p</i> < 0.001. Follow-up endoscopy was performed by 44% of EE–C/D patients. Unmarried patients compared to married ones were less adherent (adjusted OR = 0.23; 95% CI 0.08–0.69, <i>p</i> < 0.001). Conclusions: Patients with esophagitis (EE–A/B) were more adherent to medical therapy when compared to patients with more severe esophagitis (EE–C/D). |
| first_indexed | 2024-03-10T01:10:06Z |
| format | Article |
| id | doaj.art-3a4e22aef7f945dea5edee8f9af2585a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:10:06Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3a4e22aef7f945dea5edee8f9af2585a2023-11-23T14:18:28ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011111319610.3390/jcm11113196Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective StudyAmir Mari0Wasef Na’amnih1Aiman Gahshan2Helal Saied Ahmad3Tawfik Khoury4Khitam Muhsen5Gastroenterology Department, Nazareth Hospital, Azrieli Faculty of Medicine, Bar Ilan University, Ramat Gan 5290002, IsraelDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, IsraelInternal Medicine Department, Nazareth Hospital, Azrieli Faculty of Medicine, Bar Ilan University, Ramat Gan 5290002, IsraelGastroenterology Department, Nazareth Hospital, Azrieli Faculty of Medicine, Bar Ilan University, Ramat Gan 5290002, IsraelGastroenterology Department, Nazareth Hospital, Azrieli Faculty of Medicine, Bar Ilan University, Ramat Gan 5290002, IsraelDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, IsraelPurpose: Gastro-esophageal reflux disease (GERD) is prevalent and causes erosive esophagitis (EE) with varying degrees of severity (A to D according to the Los Angeles Classification). Adherence to medical therapy is crucial for treatment success. We compared adherence to treatment recommendations between patients with EE grades C/D and A/B. Methods: A follow-up study was conducted during 2019–2020 among GERD patients who underwent a diagnostic gastroscopy 1–4 years earlier. Telephone interviews were conducted with patients diagnosed with severe EE grades C/D (n = 99) and randomly selected patients with mild–moderate EE grades A/B (n = 50). Patients with grades A/B were classified as adherent if they took proton pump inhibitors (PPIs) for 2–3 months as recommended. Patients with grades C/D were classified as adherent if they took medications for a prolonged period (>6 months) and performed a follow-up endoscopy as recommended. Results: The mean age of the participants was 44.6 years (SD = 15.1). The mean duration of PPIs therapy in patients with EE grades A/B was 9.4 months (SD = 8.7). Fourteen (14.2%) patients with EE grades A/B were non-adherent to treatment, compared to 21 (40.8%) patients with EE grades of C/D: adjusted OR = 0.06; CI 95% 0.02–0.18, <i>p</i> < 0.001. Follow-up endoscopy was performed by 44% of EE–C/D patients. Unmarried patients compared to married ones were less adherent (adjusted OR = 0.23; 95% CI 0.08–0.69, <i>p</i> < 0.001). Conclusions: Patients with esophagitis (EE–A/B) were more adherent to medical therapy when compared to patients with more severe esophagitis (EE–C/D).https://www.mdpi.com/2077-0383/11/11/3196reflux esophagitisgastroscopyadherence to treatmentdietmedications |
| spellingShingle | Amir Mari Wasef Na’amnih Aiman Gahshan Helal Saied Ahmad Tawfik Khoury Khitam Muhsen Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective Study Journal of Clinical Medicine reflux esophagitis gastroscopy adherence to treatment diet medications |
| title | Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective Study |
| title_full | Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective Study |
| title_fullStr | Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective Study |
| title_full_unstemmed | Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective Study |
| title_short | Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective Study |
| title_sort | comparison in adherence to treatment between patients with mild moderate and severe reflux esophagitis a prospective study |
| topic | reflux esophagitis gastroscopy adherence to treatment diet medications |
| url | https://www.mdpi.com/2077-0383/11/11/3196 |
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