AR-13, a Celecoxib Derivative, Directly Kills Francisella In Vitro and Aids Clearance and Mouse Survival In Vivo

AR-13, a Celecoxib Derivative, Directly Kills Francisella In Vitro and Aids Clearance and Mouse Survival In Vivo

Francisella tularensis (F. tularensis) is the causative agent of tularemia and is classified as a Tier 1 select agent. No licensed vaccine is currently available in the United States and treatment of tularemia is confined to few antibiotics. In this study, we demonstrate that AR-13, a derivative of...

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Bibliographic Details
Main Authors: Ky V. Hoang, Haley E. Adcox, James R. Fitch, David M. Gordon, Heather M. Curry, Larry S. Schlesinger, Peter White, John S. Gunn
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Microbiology
Subjects:
AR-13
Francisella
antimicrobials
efflux pump
celecoxib
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01695/full

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