IMMUNOLOGICAL FEATURES IN LIVER CIRRHOSIS INDUCED BY HEPATITIS B VIRUS
Abstract. A comparative analysis of immunological data was performed in the patients with HBV-induced liver cirrhosis, and in a group of patients with acute and chronic viral hepatitis B (AVHB, CVHB). Activation of B cell immune compartment (increase in CD22+ lymphocytes and IL4, circulating immune...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/246 |
| Summary: | Abstract. A comparative analysis of immunological data was performed in the patients with HBV-induced liver cirrhosis, and in a group of patients with acute and chronic viral hepatitis B (AVHB, CVHB). Activation of B cell immune compartment (increase in CD22+ lymphocytes and IL4, circulating immune complexes in blood) was demonstrated in patients with liver cirrhosis, being also associated with increased numbers of CD16+ lymphocytes and T-cell deficiency. It was revealed that the differences are most expressed upon comparison of immunologic data from the patients with liver cirrhosis, and AVHB followed by clearance of the virus. When comparing these groups, the differences in immunological state between the patients with liver cirrhosis and CVHB did not depend on the phase of viral replication or integration. |
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| ISSN: | 1563-0625 2313-741X |