Antagonization of OX<sub>1</sub> Receptor Potentiates CB<sub>2</sub> Receptor Function in Microglia from APP<sub>Sw/Ind</sub> Mice Model

Antagonization of OX<sub>1</sub> Receptor Potentiates CB<sub>2</sub> Receptor Function in Microglia from APP<sub>Sw/Ind</sub> Mice Model

Microdialysis assays demonstrated a possible role of orexin in the regulation of amyloid beta peptide (Aß) levels in the hippocampal interstitial fluid in the APP transgenic model. CB<sub>2</sub>R is overexpressed in activated microglia, showing a neuroprotective effect. These two recept...

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Bibliographic Details
Main Authors: Iu Raïch, Joan Biel Rebassa, Jaume Lillo, Arnau Cordomi, Rafael Rivas-Santisteban, Alejandro Lillo, Irene Reyes-Resina, Rafael Franco, Gemma Navarro
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
orexin
cannabinoids
Alzheimer’s disease
activated microglia
Online Access:https://www.mdpi.com/1422-0067/23/21/12801

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https://www.mdpi.com/1422-0067/23/21/12801

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