<i>Sasa quelpaertensis</i> Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats
Background: Increased dietary fructose consumption is closely associated with lipid and glucose metabolic disorders. <i>Sasa quelpaertensis</i> Nakai possesses various health-promoting properties, but there has been no research on its protective effect against fructose-induced metabolic...
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/12/3762 |
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| author | Jeong Yong Park Mi Gyeong Jang Jung Min Oh Hee Chul Ko Sung-Pyo Hur Jae-Won Kim Songyee Baek Se-Jae Kim |
| author_facet | Jeong Yong Park Mi Gyeong Jang Jung Min Oh Hee Chul Ko Sung-Pyo Hur Jae-Won Kim Songyee Baek Se-Jae Kim |
| author_sort | Jeong Yong Park |
| collection | DOAJ |
| description | Background: Increased dietary fructose consumption is closely associated with lipid and glucose metabolic disorders. <i>Sasa quelpaertensis</i> Nakai possesses various health-promoting properties, but there has been no research on its protective effect against fructose-induced metabolic dysfunction. In this study, we investigated the effects of <i>S. quelpaertensis</i> leaf extract (SQE) on metabolic dysfunction in high-fructose-diet-fed rats. Methods: Animals were fed a 46% carbohydrate diet, a 60% high-fructose diet, or a 60% high-fructose diet with SQE (500 mg/kg of body weight (BW)/day) in drinking water for 16 weeks. Serum biochemical parameters were measured and the effects of SQE on hepatic histology, protein expression, and transcriptome profiles were investigated. Results: SQE improved dyslipidemia and insulin resistance induced in high-fructose-diet-fed rats. SQE ameliorated the lipid accumulation and inflammatory response in liver tissues by modulating the expressions of key proteins related to lipid metabolism and antioxidant response. SQE significantly enriched the genes related to the metabolic pathway, namely, the tumor necrosis factor (TNF) signaling pathway and the PI3K-Akt signaling pathway. Conclusions: SQE could effectively prevent dyslipidemia, insulin resistance, and hepatic lipid accumulation by regulation of metabolism-related gene expressions, suggesting its role as a functional ingredient to prevent lifestyle-related metabolic disorders. |
| first_indexed | 2024-03-10T14:15:23Z |
| format | Article |
| id | doaj.art-3a51382120c94398b51795d9194389c3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:15:23Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3a51382120c94398b51795d9194389c32023-11-20T23:47:15ZengMDPI AGNutrients2072-66432020-12-011212376210.3390/nu12123762<i>Sasa quelpaertensis</i> Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed RatsJeong Yong Park0Mi Gyeong Jang1Jung Min Oh2Hee Chul Ko3Sung-Pyo Hur4Jae-Won Kim5Songyee Baek6Se-Jae Kim7Department of Biology, Jeju National University, Jeju 63243, KoreaDepartment of Biology, Jeju National University, Jeju 63243, KoreaDepartment of Biology, Jeju National University, Jeju 63243, KoreaBiotech Regional Innovation Center, Jeju Nation University, Jeju 63423, KoreaJeju International Marine Science Research & Logistics Center, Korea Institute of Ocean Science & Technology, Gujwa, Jeju 63349, KoreaBiotech Regional Innovation Center, Jeju Nation University, Jeju 63423, KoreaBiotech Regional Innovation Center, Jeju Nation University, Jeju 63423, KoreaDepartment of Biology, Jeju National University, Jeju 63243, KoreaBackground: Increased dietary fructose consumption is closely associated with lipid and glucose metabolic disorders. <i>Sasa quelpaertensis</i> Nakai possesses various health-promoting properties, but there has been no research on its protective effect against fructose-induced metabolic dysfunction. In this study, we investigated the effects of <i>S. quelpaertensis</i> leaf extract (SQE) on metabolic dysfunction in high-fructose-diet-fed rats. Methods: Animals were fed a 46% carbohydrate diet, a 60% high-fructose diet, or a 60% high-fructose diet with SQE (500 mg/kg of body weight (BW)/day) in drinking water for 16 weeks. Serum biochemical parameters were measured and the effects of SQE on hepatic histology, protein expression, and transcriptome profiles were investigated. Results: SQE improved dyslipidemia and insulin resistance induced in high-fructose-diet-fed rats. SQE ameliorated the lipid accumulation and inflammatory response in liver tissues by modulating the expressions of key proteins related to lipid metabolism and antioxidant response. SQE significantly enriched the genes related to the metabolic pathway, namely, the tumor necrosis factor (TNF) signaling pathway and the PI3K-Akt signaling pathway. Conclusions: SQE could effectively prevent dyslipidemia, insulin resistance, and hepatic lipid accumulation by regulation of metabolism-related gene expressions, suggesting its role as a functional ingredient to prevent lifestyle-related metabolic disorders.https://www.mdpi.com/2072-6643/12/12/3762<i>Sasa quelpaertensis</i>dyslipidemiahigh-fructose dietinsulin resistancemetabolic dysfunction |
| spellingShingle | Jeong Yong Park Mi Gyeong Jang Jung Min Oh Hee Chul Ko Sung-Pyo Hur Jae-Won Kim Songyee Baek Se-Jae Kim <i>Sasa quelpaertensis</i> Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats Nutrients <i>Sasa quelpaertensis</i> dyslipidemia high-fructose diet insulin resistance metabolic dysfunction |
| title | <i>Sasa quelpaertensis</i> Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats |
| title_full | <i>Sasa quelpaertensis</i> Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats |
| title_fullStr | <i>Sasa quelpaertensis</i> Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats |
| title_full_unstemmed | <i>Sasa quelpaertensis</i> Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats |
| title_short | <i>Sasa quelpaertensis</i> Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats |
| title_sort | i sasa quelpaertensis i leaf extract ameliorates dyslipidemia insulin resistance and hepatic lipid accumulation in high fructose diet fed rats |
| topic | <i>Sasa quelpaertensis</i> dyslipidemia high-fructose diet insulin resistance metabolic dysfunction |
| url | https://www.mdpi.com/2072-6643/12/12/3762 |
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