Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis
Familial adenomatous polyposis (FAP) is a rare, hereditary disease characterized by the presence of 100 or more adenomas distributed throughout the colon and rectum. If untreated, colorectal cancer develops in almost 100% of FAP patients. As prophylactic treatment, proctocolectomy with ileal pouch-a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Japan Society of Coloproctology
2017-07-01
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| Series: | Journal of the Anus, Rectum and Colon |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jarc/1/3/1_/_pdf/-char/en |
| _version_ | 1818994225507729408 |
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| author | Emiko Takeshita Toshiyuki Enomoto Yoshihisa Saida |
| author_facet | Emiko Takeshita Toshiyuki Enomoto Yoshihisa Saida |
| author_sort | Emiko Takeshita |
| collection | DOAJ |
| description | Familial adenomatous polyposis (FAP) is a rare, hereditary disease characterized by the presence of 100 or more adenomas distributed throughout the colon and rectum. If untreated, colorectal cancer develops in almost 100% of FAP patients. As prophylactic treatment, proctocolectomy with ileal pouch-anal anastomosis remains the surgical treatment of choice. High rates of postoperative complications, however, have been reported with this procedure, including bowel dysfunction, incontinence, and reduced female fecundity. Some novel strategies for preventing hereditary colon cancers have been reported. This review summarizes alternative treatments, including the laparoscopic approach, chemoprevention, endoscopic management, and subtotal colectomy combined with endoscopic treatment, for prophylaxis of colorectal cancer in FAP patients. |
| first_indexed | 2024-12-20T20:54:34Z |
| format | Article |
| id | doaj.art-3a515fb61d58455b8ee1aa314dc80b6b |
| institution | Directory Open Access Journal |
| issn | 2432-3853 |
| language | English |
| last_indexed | 2024-12-20T20:54:34Z |
| publishDate | 2017-07-01 |
| publisher | The Japan Society of Coloproctology |
| record_format | Article |
| series | Journal of the Anus, Rectum and Colon |
| spelling | doaj.art-3a515fb61d58455b8ee1aa314dc80b6b2022-12-21T19:26:50ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532017-07-0113747710.23922 /jarc.2017-007Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposisEmiko Takeshita0Toshiyuki Enomoto1Yoshihisa Saida2Department of Surgery, Toho University Ohashi Medical CenterDepartment of Surgery, Toho University Ohashi Medical CenterDepartment of Surgery, Toho University Ohashi Medical CenterFamilial adenomatous polyposis (FAP) is a rare, hereditary disease characterized by the presence of 100 or more adenomas distributed throughout the colon and rectum. If untreated, colorectal cancer develops in almost 100% of FAP patients. As prophylactic treatment, proctocolectomy with ileal pouch-anal anastomosis remains the surgical treatment of choice. High rates of postoperative complications, however, have been reported with this procedure, including bowel dysfunction, incontinence, and reduced female fecundity. Some novel strategies for preventing hereditary colon cancers have been reported. This review summarizes alternative treatments, including the laparoscopic approach, chemoprevention, endoscopic management, and subtotal colectomy combined with endoscopic treatment, for prophylaxis of colorectal cancer in FAP patients.https://www.jstage.jst.go.jp/article/jarc/1/3/1_/_pdf/-char/enfamilial adenomatous polyposistotal proctocolectomyileal pouch-anal anastomosis (IPAA)ileorectal anastomosis (IRA)chemopreventionendoscopic management |
| spellingShingle | Emiko Takeshita Toshiyuki Enomoto Yoshihisa Saida Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis Journal of the Anus, Rectum and Colon familial adenomatous polyposis total proctocolectomy ileal pouch-anal anastomosis (IPAA) ileorectal anastomosis (IRA) chemoprevention endoscopic management |
| title | Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis |
| title_full | Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis |
| title_fullStr | Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis |
| title_full_unstemmed | Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis |
| title_short | Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis |
| title_sort | alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis |
| topic | familial adenomatous polyposis total proctocolectomy ileal pouch-anal anastomosis (IPAA) ileorectal anastomosis (IRA) chemoprevention endoscopic management |
| url | https://www.jstage.jst.go.jp/article/jarc/1/3/1_/_pdf/-char/en |
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