Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD)
Mitochondrial dysfunction is known to contribute to mitochondrial diseases, as well as to a variety of aging-based pathologies. Mitochondria have their own genomes (mitochondrial DNA (mtDNA)) and the abnormalities, such as point mutations, deletions, and copy number variations, are involved in mitoc...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/12/6634 |
| _version_ | 1797529344488243200 |
|---|---|
| author | Hisanori Fukunaga |
| author_facet | Hisanori Fukunaga |
| author_sort | Hisanori Fukunaga |
| collection | DOAJ |
| description | Mitochondrial dysfunction is known to contribute to mitochondrial diseases, as well as to a variety of aging-based pathologies. Mitochondria have their own genomes (mitochondrial DNA (mtDNA)) and the abnormalities, such as point mutations, deletions, and copy number variations, are involved in mitochondrial dysfunction. In recent years, several epidemiological studies and animal experiments have supported the Developmental Origin of Health and Disease (DOHaD) theory, which states that the environment during fetal life influences the predisposition to disease and the risk of morbidity in adulthood. Mitochondria play a central role in energy production, as well as in various cellular functions, such as apoptosis, lipid metabolism, and calcium metabolism. In terms of the DOHaD theory, mtDNA copy number may be a mediator of health and disease. This paper summarizes the results of recent epidemiological studies on the relationship between environmental factors and mtDNA copy number during pregnancy from the perspective of DOHaD theory. The results of these studies suggest a hypothesis that mtDNA copy number may reflect environmental influences during fetal life and possibly serve as a surrogate marker of health risks in adulthood. |
| first_indexed | 2024-03-10T10:12:30Z |
| format | Article |
| id | doaj.art-3a52ce79e73e4186ab582154058e5df2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:12:30Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3a52ce79e73e4186ab582154058e5df22023-11-22T01:02:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212663410.3390/ijms22126634Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD)Hisanori Fukunaga0Center for Environmental and Health Sciences, Hokkaido University, N12 W7 Kita-ku, Sapporo 060-0812, JapanMitochondrial dysfunction is known to contribute to mitochondrial diseases, as well as to a variety of aging-based pathologies. Mitochondria have their own genomes (mitochondrial DNA (mtDNA)) and the abnormalities, such as point mutations, deletions, and copy number variations, are involved in mitochondrial dysfunction. In recent years, several epidemiological studies and animal experiments have supported the Developmental Origin of Health and Disease (DOHaD) theory, which states that the environment during fetal life influences the predisposition to disease and the risk of morbidity in adulthood. Mitochondria play a central role in energy production, as well as in various cellular functions, such as apoptosis, lipid metabolism, and calcium metabolism. In terms of the DOHaD theory, mtDNA copy number may be a mediator of health and disease. This paper summarizes the results of recent epidemiological studies on the relationship between environmental factors and mtDNA copy number during pregnancy from the perspective of DOHaD theory. The results of these studies suggest a hypothesis that mtDNA copy number may reflect environmental influences during fetal life and possibly serve as a surrogate marker of health risks in adulthood.https://www.mdpi.com/1422-0067/22/12/6634DOHaDenvironmental stressmitochondrial DNA copy numberpregnancyrisk management |
| spellingShingle | Hisanori Fukunaga Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD) International Journal of Molecular Sciences DOHaD environmental stress mitochondrial DNA copy number pregnancy risk management |
| title | Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD) |
| title_full | Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD) |
| title_fullStr | Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD) |
| title_full_unstemmed | Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD) |
| title_short | Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD) |
| title_sort | mitochondrial dna copy number and developmental origins of health and disease dohad |
| topic | DOHaD environmental stress mitochondrial DNA copy number pregnancy risk management |
| url | https://www.mdpi.com/1422-0067/22/12/6634 |
| work_keys_str_mv | AT hisanorifukunaga mitochondrialdnacopynumberanddevelopmentaloriginsofhealthanddiseasedohad |