The Role of Calcium and Iron Homeostasis in Parkinson’s Disease
Calcium and iron are essential elements that regulate many important processes of eukaryotic cells. Failure to maintain homeostasis of calcium and iron causes cell dysfunction or even death. PD (Parkinson’s disease) is the second most common neurological disorder in humans, for which there are curre...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/14/1/88 |
| _version_ | 1797344471992500224 |
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| author | Ji Wang Jindong Zhao Kunying Zhao Shangpeng Wu Xinglong Chen Weiyan Hu |
| author_facet | Ji Wang Jindong Zhao Kunying Zhao Shangpeng Wu Xinglong Chen Weiyan Hu |
| author_sort | Ji Wang |
| collection | DOAJ |
| description | Calcium and iron are essential elements that regulate many important processes of eukaryotic cells. Failure to maintain homeostasis of calcium and iron causes cell dysfunction or even death. PD (Parkinson’s disease) is the second most common neurological disorder in humans, for which there are currently no viable treatment options or effective strategies to cure and delay progression. Pathological hallmarks of PD, such as dopaminergic neuronal death and intracellular α-synuclein deposition, are closely involved in perturbations of iron and calcium homeostasis and accumulation. Here, we summarize the mechanisms by which Ca<sup>2+</sup> signaling influences or promotes PD progression and the main mechanisms involved in ferroptosis in Parkinson’s disease. Understanding the mechanisms by which calcium and iron imbalances contribute to the progression of this disease is critical to developing effective treatments to combat this devastating neurological disorder. |
| first_indexed | 2024-03-08T11:03:07Z |
| format | Article |
| id | doaj.art-3a5413586c2e403ba1deb2b43ecfbcd9 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-08T11:03:07Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-3a5413586c2e403ba1deb2b43ecfbcd92024-01-26T15:25:13ZengMDPI AGBrain Sciences2076-34252024-01-011418810.3390/brainsci14010088The Role of Calcium and Iron Homeostasis in Parkinson’s DiseaseJi Wang0Jindong Zhao1Kunying Zhao2Shangpeng Wu3Xinglong Chen4Weiyan Hu5School of Chinese Materia Medica & Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming 650500, ChinaSchool of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaSchool of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaSchool of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaSchool of Chinese Materia Medica & Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming 650500, ChinaSchool of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaCalcium and iron are essential elements that regulate many important processes of eukaryotic cells. Failure to maintain homeostasis of calcium and iron causes cell dysfunction or even death. PD (Parkinson’s disease) is the second most common neurological disorder in humans, for which there are currently no viable treatment options or effective strategies to cure and delay progression. Pathological hallmarks of PD, such as dopaminergic neuronal death and intracellular α-synuclein deposition, are closely involved in perturbations of iron and calcium homeostasis and accumulation. Here, we summarize the mechanisms by which Ca<sup>2+</sup> signaling influences or promotes PD progression and the main mechanisms involved in ferroptosis in Parkinson’s disease. Understanding the mechanisms by which calcium and iron imbalances contribute to the progression of this disease is critical to developing effective treatments to combat this devastating neurological disorder.https://www.mdpi.com/2076-3425/14/1/88Parkinson’scalciumferroptosishomeostasis |
| spellingShingle | Ji Wang Jindong Zhao Kunying Zhao Shangpeng Wu Xinglong Chen Weiyan Hu The Role of Calcium and Iron Homeostasis in Parkinson’s Disease Brain Sciences Parkinson’s calcium ferroptosis homeostasis |
| title | The Role of Calcium and Iron Homeostasis in Parkinson’s Disease |
| title_full | The Role of Calcium and Iron Homeostasis in Parkinson’s Disease |
| title_fullStr | The Role of Calcium and Iron Homeostasis in Parkinson’s Disease |
| title_full_unstemmed | The Role of Calcium and Iron Homeostasis in Parkinson’s Disease |
| title_short | The Role of Calcium and Iron Homeostasis in Parkinson’s Disease |
| title_sort | role of calcium and iron homeostasis in parkinson s disease |
| topic | Parkinson’s calcium ferroptosis homeostasis |
| url | https://www.mdpi.com/2076-3425/14/1/88 |
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