Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine
The complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in the development of drug resistance. Tradition...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/9/1122 |
| _version_ | 1797518135426809856 |
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| author | Jisoo Kim Jinah Jang Dong-Woo Cho |
| author_facet | Jisoo Kim Jinah Jang Dong-Woo Cho |
| author_sort | Jisoo Kim |
| collection | DOAJ |
| description | The complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in the development of drug resistance. Traditional animal models used in drug discovery studies have been associated with feasibility issues that limit the recapitulation of human functions; thus, in vitro models have been developed to reconstruct the human cancer system. However, conventional two-dimensional and three-dimensional (3D) in vitro cancer models are limited in their ability to emulate complex cancer microenvironments. Advances in technologies, including bioprinting and cancer microenvironment reconstruction, have demonstrated the potential to overcome some of the limitations of conventional models. This study reviews some representative bioprinted in vitro models used in cancer research, particularly fabrication strategies for modeling and consideration of essential factors needed for the reconstruction of the cancer microenvironment. In addition, we highlight recent studies that applied such models, including application in precision medicine using advanced bioprinting technologies to fabricate biomimetic cancer models. Furthermore, we discuss current challenges in 3D bioprinting and suggest possible strategies to construct in vitro models that better mimic the pathophysiology of the cancer microenvironment for application in clinical settings. |
| first_indexed | 2024-03-10T07:25:54Z |
| format | Article |
| id | doaj.art-3a5c0617631a467e874e74bb5075f04c |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T07:25:54Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-3a5c0617631a467e874e74bb5075f04c2023-11-22T14:16:55ZengMDPI AGMicromachines2072-666X2021-09-01129112210.3390/mi12091122Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision MedicineJisoo Kim0Jinah Jang1Dong-Woo Cho2School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaSchool of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaSchool of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaThe complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in the development of drug resistance. Traditional animal models used in drug discovery studies have been associated with feasibility issues that limit the recapitulation of human functions; thus, in vitro models have been developed to reconstruct the human cancer system. However, conventional two-dimensional and three-dimensional (3D) in vitro cancer models are limited in their ability to emulate complex cancer microenvironments. Advances in technologies, including bioprinting and cancer microenvironment reconstruction, have demonstrated the potential to overcome some of the limitations of conventional models. This study reviews some representative bioprinted in vitro models used in cancer research, particularly fabrication strategies for modeling and consideration of essential factors needed for the reconstruction of the cancer microenvironment. In addition, we highlight recent studies that applied such models, including application in precision medicine using advanced bioprinting technologies to fabricate biomimetic cancer models. Furthermore, we discuss current challenges in 3D bioprinting and suggest possible strategies to construct in vitro models that better mimic the pathophysiology of the cancer microenvironment for application in clinical settings.https://www.mdpi.com/2072-666X/12/9/1122cancer biologycancer modeltissue engineeringbiofabricationcancer microenvironment |
| spellingShingle | Jisoo Kim Jinah Jang Dong-Woo Cho Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine Micromachines cancer biology cancer model tissue engineering biofabrication cancer microenvironment |
| title | Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine |
| title_full | Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine |
| title_fullStr | Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine |
| title_full_unstemmed | Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine |
| title_short | Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine |
| title_sort | recapitulating the cancer microenvironment using bioprinting technology for precision medicine |
| topic | cancer biology cancer model tissue engineering biofabrication cancer microenvironment |
| url | https://www.mdpi.com/2072-666X/12/9/1122 |
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