Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications

Abstract Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell membranes offer an opportunity to unite natural cell membran...

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Main Authors: Yao Liu, Jingshan Luo, Xiaojia Chen, Wei Liu, Tongkai Chen
Format: Article
Language:English
Published: SpringerOpen 2019-11-01
Series:Nano-Micro Letters
Subjects:
Online Access:http://link.springer.com/article/10.1007/s40820-019-0330-9
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author Yao Liu
Jingshan Luo
Xiaojia Chen
Wei Liu
Tongkai Chen
author_facet Yao Liu
Jingshan Luo
Xiaojia Chen
Wei Liu
Tongkai Chen
author_sort Yao Liu
collection DOAJ
description Abstract Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material. The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo, allowing for the execution of targeted functions. Although cell membrane-coated NPs offer clear advantages, much work remains before they can be applied in clinical practice. In this review, we first provide a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques. Next, we focus on the functions and applications of various cell membrane types. In addition, we collate model drugs used in cell membrane coating technology, and review the patent applications related to this technology from the past 10 years. Finally, we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.
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spelling doaj.art-3a5f5df7d9cf495bbb711e4a033f9f402022-12-22T00:27:56ZengSpringerOpenNano-Micro Letters2311-67062150-55512019-11-0111114610.1007/s40820-019-0330-9Cell Membrane Coating Technology: A Promising Strategy for Biomedical ApplicationsYao Liu0Jingshan Luo1Xiaojia Chen2Wei Liu3Tongkai Chen4Science and Technology Innovation Center, Guangzhou University of Chinese MedicineScience and Technology Innovation Center, Guangzhou University of Chinese MedicineState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauKey Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan UniversityScience and Technology Innovation Center, Guangzhou University of Chinese MedicineAbstract Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material. The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo, allowing for the execution of targeted functions. Although cell membrane-coated NPs offer clear advantages, much work remains before they can be applied in clinical practice. In this review, we first provide a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques. Next, we focus on the functions and applications of various cell membrane types. In addition, we collate model drugs used in cell membrane coating technology, and review the patent applications related to this technology from the past 10 years. Finally, we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.http://link.springer.com/article/10.1007/s40820-019-0330-9Cell membraneBiomimetic nanoparticlesCancer therapyImmune modulationDetoxification
spellingShingle Yao Liu
Jingshan Luo
Xiaojia Chen
Wei Liu
Tongkai Chen
Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
Nano-Micro Letters
Cell membrane
Biomimetic nanoparticles
Cancer therapy
Immune modulation
Detoxification
title Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
title_full Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
title_fullStr Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
title_full_unstemmed Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
title_short Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
title_sort cell membrane coating technology a promising strategy for biomedical applications
topic Cell membrane
Biomimetic nanoparticles
Cancer therapy
Immune modulation
Detoxification
url http://link.springer.com/article/10.1007/s40820-019-0330-9
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