Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire Study
Rapid eye movement (REM) sleep behavior disorder (RBD) is generally common among males and is an established risk factor for neurodegenerative diseases. As the population ages, the prevalence of α-synucleinopathy (such as Parkinson’s disease) is increasing. Additionally, the number of female patient...
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| author | Mamiko Mano Atsuhiko Nomura Ryujiro Sasanabe |
| author_facet | Mamiko Mano Atsuhiko Nomura Ryujiro Sasanabe |
| author_sort | Mamiko Mano |
| collection | DOAJ |
| description | Rapid eye movement (REM) sleep behavior disorder (RBD) is generally common among males and is an established risk factor for neurodegenerative diseases. As the population ages, the prevalence of α-synucleinopathy (such as Parkinson’s disease) is increasing. Additionally, the number of female patients is increasing in Japan. Therefore, we aimed to clarify the clinical characteristics of RBD from the perspective of gender differences in the Japanese population. The proportion of male RBD patients (65.2%) was significantly higher than that of female patients (34.8%). Additionally, female patients (70.5 ± 8.2 years) were significantly older than male patients (67.9 ± 8.0 years, <i>p</i> < 0.05). The mean score on the RBD Screening Questionnaire was significantly higher in male patients than in female (8.6 ± 2.9 vs. 7.7 ± 3.1, <i>p</i> < 0.05), while the mean score on the Pittsburgh Sleep Quality Index was significantly higher in males (5.9 ± 3.8 vs. 7.2 ± 3.600, <i>p</i> < 0.001). The Self-rating Depression Scale in females was 41.7 ± 8.5, and they were more likely to show depressive tendencies than males. In polysomnography, higher rates of obstructive sleep apnea and longer duration of stage N1 sleep were detected in males. After adjusting for age, BMI, and polysomnographic parameters, we found that female RBD patients had significantly worse sleep quality and rates of depression compared to male patients. |
| first_indexed | 2024-03-08T03:53:31Z |
| format | Article |
| id | doaj.art-3a6560a5cb984ce1ba5f5ec903e63a87 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T03:53:31Z |
| publishDate | 2024-02-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-3a6560a5cb984ce1ba5f5ec903e63a872024-02-09T15:16:53ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-0113391410.3390/jcm13030914Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire StudyMamiko Mano0Atsuhiko Nomura1Ryujiro Sasanabe2Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University, Nagakute 480-1195, JapanDepartment of Sleep Medicine and Sleep Disorders Center, Aichi Medical University, Nagakute 480-1195, JapanDepartment of Sleep Medicine and Sleep Disorders Center, Aichi Medical University, Nagakute 480-1195, JapanRapid eye movement (REM) sleep behavior disorder (RBD) is generally common among males and is an established risk factor for neurodegenerative diseases. As the population ages, the prevalence of α-synucleinopathy (such as Parkinson’s disease) is increasing. Additionally, the number of female patients is increasing in Japan. Therefore, we aimed to clarify the clinical characteristics of RBD from the perspective of gender differences in the Japanese population. The proportion of male RBD patients (65.2%) was significantly higher than that of female patients (34.8%). Additionally, female patients (70.5 ± 8.2 years) were significantly older than male patients (67.9 ± 8.0 years, <i>p</i> < 0.05). The mean score on the RBD Screening Questionnaire was significantly higher in male patients than in female (8.6 ± 2.9 vs. 7.7 ± 3.1, <i>p</i> < 0.05), while the mean score on the Pittsburgh Sleep Quality Index was significantly higher in males (5.9 ± 3.8 vs. 7.2 ± 3.600, <i>p</i> < 0.001). The Self-rating Depression Scale in females was 41.7 ± 8.5, and they were more likely to show depressive tendencies than males. In polysomnography, higher rates of obstructive sleep apnea and longer duration of stage N1 sleep were detected in males. After adjusting for age, BMI, and polysomnographic parameters, we found that female RBD patients had significantly worse sleep quality and rates of depression compared to male patients.https://www.mdpi.com/2077-0383/13/3/914REM sleep behavior disordergender differencessleep qualitydepressionpolysomnography |
| spellingShingle | Mamiko Mano Atsuhiko Nomura Ryujiro Sasanabe Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire Study Journal of Clinical Medicine REM sleep behavior disorder gender differences sleep quality depression polysomnography |
| title | Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire Study |
| title_full | Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire Study |
| title_fullStr | Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire Study |
| title_full_unstemmed | Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire Study |
| title_short | Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire Study |
| title_sort | gender difference in rem sleep behavior disorder in japanese population polysomnography and sleep questionnaire study |
| topic | REM sleep behavior disorder gender differences sleep quality depression polysomnography |
| url | https://www.mdpi.com/2077-0383/13/3/914 |
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