The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy
Objective: To investigate and prove that aspirin protects, or at least attenuates amikacin ototoxicity in humans. Method: This study was conducted in 60 patients that completed all requirements .The patients were divided into two groups: • Control group: receive placebo treatment. • Drug–treated gr...
| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad/ Al-Kindy College of Medicine
2011-06-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/659 |
| _version_ | 1818481318620561408 |
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| author | Estabraq M. Mahdi |
| author_facet | Estabraq M. Mahdi |
| author_sort | Estabraq M. Mahdi |
| collection | DOAJ |
| description |
Objective: To investigate and prove that aspirin
protects, or at least attenuates amikacin ototoxicity in
humans.
Method: This study was conducted in 60 patients that
completed all
requirements .The patients were divided into two
groups:
• Control group: receive placebo treatment.
• Drug–treated group: They receive aspirin
coated tablets (1.5gm/ day), 500mg 8 hourly.
Both groups had similar aspects regarding the gender,
age and weight. The duration of therapy was 7 days
and dosage of amikacin was 1gm/day (500mg 12
hourly).
Results: Comparison of Audiometry test in
Ear/Nose/Throat (E.N.T.) Department (Pure Tone
Audiometry) at 1000 Hertz (Hz), 2000 Hz, 4000 Hz,
and 8000 Hz showed significant differences between
mean Audiometry at 250Hz was significantly different
only at 8th and 15th day while at the frequency of 500Hz
the difference was significant at the 15thday only.
Conclusion: In present study, we had shown that
aspirin can protect the patients who are receiving
amikacin therapy from it' s ototoxicity.
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| first_indexed | 2024-12-10T11:33:19Z |
| format | Article |
| id | doaj.art-3a65f3712226428f9a9e3ce1346b29d3 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-12-10T11:33:19Z |
| publishDate | 2011-06-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-3a65f3712226428f9a9e3ce1346b29d32022-12-22T01:50:29ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652011-06-0171The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin TherapyEstabraq M. Mahdi0From the department of Pharmacology , AL-kindy College of Medicine, University of Baghdad Objective: To investigate and prove that aspirin protects, or at least attenuates amikacin ototoxicity in humans. Method: This study was conducted in 60 patients that completed all requirements .The patients were divided into two groups: • Control group: receive placebo treatment. • Drug–treated group: They receive aspirin coated tablets (1.5gm/ day), 500mg 8 hourly. Both groups had similar aspects regarding the gender, age and weight. The duration of therapy was 7 days and dosage of amikacin was 1gm/day (500mg 12 hourly). Results: Comparison of Audiometry test in Ear/Nose/Throat (E.N.T.) Department (Pure Tone Audiometry) at 1000 Hertz (Hz), 2000 Hz, 4000 Hz, and 8000 Hz showed significant differences between mean Audiometry at 250Hz was significantly different only at 8th and 15th day while at the frequency of 500Hz the difference was significant at the 15thday only. Conclusion: In present study, we had shown that aspirin can protect the patients who are receiving amikacin therapy from it' s ototoxicity. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/659AspirinamikacinPure Tone Audiometryand ototoxicity. |
| spellingShingle | Estabraq M. Mahdi The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy مجله كليه طب الكندي Aspirin amikacin Pure Tone Audiometry and ototoxicity. |
| title | The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy |
| title_full | The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy |
| title_fullStr | The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy |
| title_full_unstemmed | The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy |
| title_short | The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy |
| title_sort | role of aspirin as otoprotective agent in patients receiving amikacin therapy |
| topic | Aspirin amikacin Pure Tone Audiometry and ototoxicity. |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/659 |
| work_keys_str_mv | AT estabraqmmahdi theroleofaspirinasotoprotectiveagentinpatientsreceivingamikacintherapy AT estabraqmmahdi roleofaspirinasotoprotectiveagentinpatientsreceivingamikacintherapy |