Corneal Epithelial Changes in Diabetic Patients: A Review
The relationship between diabetes mellitus and ocular complications has been extensively studied by many authors. Diabetic keratopathy has already been well characterized and defined as a clinical entity. This review focuses on exploring corneal epithelial changes in diabetic patients, aiming to pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3471 |
| _version_ | 1797240672038682624 |
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| author | Lidia Ladea Mihail Zemba Maria Ioana Calancea Mihai Valeriu Călțaru Christiana Diana Maria Dragosloveanu Ruxandra Coroleucă Eduard Lucian Catrina Iulian Brezean Valentin Dinu |
| author_facet | Lidia Ladea Mihail Zemba Maria Ioana Calancea Mihai Valeriu Călțaru Christiana Diana Maria Dragosloveanu Ruxandra Coroleucă Eduard Lucian Catrina Iulian Brezean Valentin Dinu |
| author_sort | Lidia Ladea |
| collection | DOAJ |
| description | The relationship between diabetes mellitus and ocular complications has been extensively studied by many authors. Diabetic keratopathy has already been well characterized and defined as a clinical entity. This review focuses on exploring corneal epithelial changes in diabetic patients, aiming to provide a pragmatic overview of the existing knowledge on this topic. The paper systematically examines alterations in corneal epithelial structure and their impact on diabetic patients. Advanced imaging techniques are also discussed for their role in precise characterization and improved diagnostics. Additionally, the paper explores the mechanisms behind corneal epithelial changes in diabetes, looking at factors such as hyperglycemia, oxidative stress, and Advanced Glycation End-Products. The impact of altered corneal epithelial integrity on barrier function and susceptibility to external issues is considered, addressing potential links to heightened proteolytic enzyme activities and delayed wound healing observed in diabetic individuals. The review also covers the practical implications of corneal epithelial changes, including the association with corneal erosions, persistent epithelial defects, and an increased risk of dry eye syndrome in diabetic patients. |
| first_indexed | 2024-04-24T18:11:09Z |
| format | Article |
| id | doaj.art-3a667eb7cd4c4d998a11f65670be597f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:11:09Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3a667eb7cd4c4d998a11f65670be597f2024-03-27T13:46:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256347110.3390/ijms25063471Corneal Epithelial Changes in Diabetic Patients: A ReviewLidia Ladea0Mihail Zemba1Maria Ioana Calancea2Mihai Valeriu Călțaru3Christiana Diana Maria Dragosloveanu4Ruxandra Coroleucă5Eduard Lucian Catrina6Iulian Brezean7Valentin Dinu8Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaBucharest Emergency Eye Hospital, 030167 Bucharest, RomaniaBucharest Emergency Eye Hospital, 030167 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaThe relationship between diabetes mellitus and ocular complications has been extensively studied by many authors. Diabetic keratopathy has already been well characterized and defined as a clinical entity. This review focuses on exploring corneal epithelial changes in diabetic patients, aiming to provide a pragmatic overview of the existing knowledge on this topic. The paper systematically examines alterations in corneal epithelial structure and their impact on diabetic patients. Advanced imaging techniques are also discussed for their role in precise characterization and improved diagnostics. Additionally, the paper explores the mechanisms behind corneal epithelial changes in diabetes, looking at factors such as hyperglycemia, oxidative stress, and Advanced Glycation End-Products. The impact of altered corneal epithelial integrity on barrier function and susceptibility to external issues is considered, addressing potential links to heightened proteolytic enzyme activities and delayed wound healing observed in diabetic individuals. The review also covers the practical implications of corneal epithelial changes, including the association with corneal erosions, persistent epithelial defects, and an increased risk of dry eye syndrome in diabetic patients.https://www.mdpi.com/1422-0067/25/6/3471corneal epithelial thicknessAS-OCTdiabetic keratopathydiabetic corneal neuropathyIVCMcorneal edema |
| spellingShingle | Lidia Ladea Mihail Zemba Maria Ioana Calancea Mihai Valeriu Călțaru Christiana Diana Maria Dragosloveanu Ruxandra Coroleucă Eduard Lucian Catrina Iulian Brezean Valentin Dinu Corneal Epithelial Changes in Diabetic Patients: A Review International Journal of Molecular Sciences corneal epithelial thickness AS-OCT diabetic keratopathy diabetic corneal neuropathy IVCM corneal edema |
| title | Corneal Epithelial Changes in Diabetic Patients: A Review |
| title_full | Corneal Epithelial Changes in Diabetic Patients: A Review |
| title_fullStr | Corneal Epithelial Changes in Diabetic Patients: A Review |
| title_full_unstemmed | Corneal Epithelial Changes in Diabetic Patients: A Review |
| title_short | Corneal Epithelial Changes in Diabetic Patients: A Review |
| title_sort | corneal epithelial changes in diabetic patients a review |
| topic | corneal epithelial thickness AS-OCT diabetic keratopathy diabetic corneal neuropathy IVCM corneal edema |
| url | https://www.mdpi.com/1422-0067/25/6/3471 |
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