The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic
Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and dur...
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/10/2926 |
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| author | Roberto Licordari Alessandro Sticchi Filippo Mancuso Alessandro Caracciolo Saverio Muscoli Fortunato Iacovelli Rossella Ruggiero Alessandra Scoccia Valeria Cammalleri Marco Pavani Marco Loffi Domenico Scordino Jayme Ferro Andrea Rognoni Andrea Buono Stefano Nava Stefano Albani Iginio Colaiori Filippo Zilio Marco Borghesi Valentina Regazzoni Stefano Benenati Fabio Pescetelli Vincenzo De Marzo Antonia Mannarini Francesco Spione Doronzo Baldassarre Michele De Benedictis Roberto Bonmassari Gian Battista Danzi Mario Galli Alfonso Ielasi Giuseppe Musumeci Fabrizio Tomai Vincenzo Pasceri Italo Porto Giuseppe Patti Gianluca Campo Antonio Colombo Antonio Micari Francesco Giannini Francesco Costa |
| author_facet | Roberto Licordari Alessandro Sticchi Filippo Mancuso Alessandro Caracciolo Saverio Muscoli Fortunato Iacovelli Rossella Ruggiero Alessandra Scoccia Valeria Cammalleri Marco Pavani Marco Loffi Domenico Scordino Jayme Ferro Andrea Rognoni Andrea Buono Stefano Nava Stefano Albani Iginio Colaiori Filippo Zilio Marco Borghesi Valentina Regazzoni Stefano Benenati Fabio Pescetelli Vincenzo De Marzo Antonia Mannarini Francesco Spione Doronzo Baldassarre Michele De Benedictis Roberto Bonmassari Gian Battista Danzi Mario Galli Alfonso Ielasi Giuseppe Musumeci Fabrizio Tomai Vincenzo Pasceri Italo Porto Giuseppe Patti Gianluca Campo Antonio Colombo Antonio Micari Francesco Giannini Francesco Costa |
| author_sort | Roberto Licordari |
| collection | DOAJ |
| description | Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients. |
| first_indexed | 2024-03-10T03:39:24Z |
| format | Article |
| id | doaj.art-3a676972c4b344008fe528b283718810 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:39:24Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3a676972c4b344008fe528b2837188102023-11-23T11:36:59ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110292610.3390/jcm11102926The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 PandemicRoberto Licordari0Alessandro Sticchi1Filippo Mancuso2Alessandro Caracciolo3Saverio Muscoli4Fortunato Iacovelli5Rossella Ruggiero6Alessandra Scoccia7Valeria Cammalleri8Marco Pavani9Marco Loffi10Domenico Scordino11Jayme Ferro12Andrea Rognoni13Andrea Buono14Stefano Nava15Stefano Albani16Iginio Colaiori17Filippo Zilio18Marco Borghesi19Valentina Regazzoni20Stefano Benenati21Fabio Pescetelli22Vincenzo De Marzo23Antonia Mannarini24Francesco Spione25Doronzo Baldassarre26Michele De Benedictis27Roberto Bonmassari28Gian Battista Danzi29Mario Galli30Alfonso Ielasi31Giuseppe Musumeci32Fabrizio Tomai33Vincenzo Pasceri34Italo Porto35Giuseppe Patti36Gianluca Campo37Antonio Colombo38Antonio Micari39Francesco Giannini40Francesco Costa41Department of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, ItalyGVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, ItalyDepartment of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, ItalyDepartment of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, ItalyDepartment of Cardiovascular Disease, Tor Vergata University, 00133 Rome, ItalyDivision of University Cardiology, Cardiothoracic Department, Policlinico University Hospital, 072006 Bari, ItalyGVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, ItalyGVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, ItalyDepartment of Cardiovascular Disease, Tor Vergata University, 00133 Rome, ItalyDepartment of Cardiology, Ospedale Civile SS Annunziata, 12038 Savigliano, ItalyDepartment of Cardiology, Ospedale di Cremona, 26100 Cremona, ItalyDivision of Cardiology, Aurelia Hospital, 00165 Rome, ItalyU.O.S.D. Cardiologia-Laboratorio di Emodinamica, Dipartimento di Emergenza, Rianimazione e Anestesia, ASST Lariana, Ospedale S. Anna, 22100 Como, ItalyDepartment of Cardiology, Azienda Ospedaliero–Universitaria Maggiore della Carità, 28100 Novara, ItalyClinical and Interventional Cardiology Unit, Istituto Clinico Sant’Ambrogio, 20149 Milan, ItalyDivision of Invasive Cardiology, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, ItalyDepartment of Cardiology, Mauriziano Hospital, 10128 Turin, ItalyAzienda Unità Sanitaria Locale, IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyU.O.C. Cardiologia, Ospedale Santa Chiara, 38121 Trento, ItalyU.O.C. Cardiologia, Ospedale Santa Chiara, 38121 Trento, ItalyDepartment of Cardiology, Ospedale di Cremona, 26100 Cremona, ItalyDipartimento CardioToracoVascolare, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, ItalyDipartimento CardioToracoVascolare, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, ItalyDipartimento CardioToracoVascolare, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, ItalyDivision of University Cardiology, Cardiothoracic Department, Policlinico University Hospital, 072006 Bari, ItalyDivision of University Cardiology, Cardiothoracic Department, Policlinico University Hospital, 072006 Bari, ItalyDepartment of Cardiology, Ospedale Civile SS Annunziata, 12038 Savigliano, ItalyDepartment of Cardiology, Ospedale Civile SS Annunziata, 12038 Savigliano, ItalyU.O.C. Cardiologia, Ospedale Santa Chiara, 38121 Trento, ItalyDepartment of Cardiology, Ospedale di Cremona, 26100 Cremona, ItalyU.O.S.D. Cardiologia-Laboratorio di Emodinamica, Dipartimento di Emergenza, Rianimazione e Anestesia, ASST Lariana, Ospedale S. Anna, 22100 Como, ItalyClinical and Interventional Cardiology Unit, Istituto Clinico Sant’Ambrogio, 20149 Milan, ItalyDepartment of Cardiology, Mauriziano Hospital, 10128 Turin, ItalyDivision of Cardiology, Aurelia Hospital, 00165 Rome, ItalyDepartment of Cardiology, San Filippo Neri Roma, 00135 Rome, ItalyDipartimento CardioToracoVascolare, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, ItalyDepartment of Cardiology, Azienda Ospedaliero–Universitaria Maggiore della Carità, 28100 Novara, ItalyCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 30010 Cona, ItalyGVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, ItalyDepartment of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, ItalyGVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, ItalyDepartment of Clinical and Experimental Medicine, Policlinic “G Martino”, University of Messina, 98124 Messina, ItalyBackground: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.https://www.mdpi.com/2077-0383/11/10/2926acute coronary syndrome (ACS)COVID-19myocardial infarction (MI)bleedingin-hospital outcomes |
| spellingShingle | Roberto Licordari Alessandro Sticchi Filippo Mancuso Alessandro Caracciolo Saverio Muscoli Fortunato Iacovelli Rossella Ruggiero Alessandra Scoccia Valeria Cammalleri Marco Pavani Marco Loffi Domenico Scordino Jayme Ferro Andrea Rognoni Andrea Buono Stefano Nava Stefano Albani Iginio Colaiori Filippo Zilio Marco Borghesi Valentina Regazzoni Stefano Benenati Fabio Pescetelli Vincenzo De Marzo Antonia Mannarini Francesco Spione Doronzo Baldassarre Michele De Benedictis Roberto Bonmassari Gian Battista Danzi Mario Galli Alfonso Ielasi Giuseppe Musumeci Fabrizio Tomai Vincenzo Pasceri Italo Porto Giuseppe Patti Gianluca Campo Antonio Colombo Antonio Micari Francesco Giannini Francesco Costa The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic Journal of Clinical Medicine acute coronary syndrome (ACS) COVID-19 myocardial infarction (MI) bleeding in-hospital outcomes |
| title | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_full | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_fullStr | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_full_unstemmed | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_short | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_sort | incidence and impact of in hospital bleeding in patients with acute coronary syndrome during the covid 19 pandemic |
| topic | acute coronary syndrome (ACS) COVID-19 myocardial infarction (MI) bleeding in-hospital outcomes |
| url | https://www.mdpi.com/2077-0383/11/10/2926 |
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