Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileus
Under physiological or pathological conditions, transient receptor potential (TRP) channel vanilloid type 1 (TRPV1) and TRP ankyrin 1 (TRPA1) possess the ability to detect a vast array of stimuli and execute diverse functions. Interestingly, increasing works have reported that activation of TRPV1 an...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661823002797 |
| _version_ | 1827794301777608704 |
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| author | Qi Liang Jing-Wen Wang Yu-Ru Bai Ruo-Lan Li Chun-Jie Wu Wei Peng |
| author_facet | Qi Liang Jing-Wen Wang Yu-Ru Bai Ruo-Lan Li Chun-Jie Wu Wei Peng |
| author_sort | Qi Liang |
| collection | DOAJ |
| description | Under physiological or pathological conditions, transient receptor potential (TRP) channel vanilloid type 1 (TRPV1) and TRP ankyrin 1 (TRPA1) possess the ability to detect a vast array of stimuli and execute diverse functions. Interestingly, increasing works have reported that activation of TRPV1 and TRPA1 could also be beneficial for ameliorating postoperative ileus (POI). Increasing research has revealed that the gastrointestinal (GI) tract is rich in TRPV1/TRPA1, which can be stimulated by capsaicin, allicin and other compounds. This activation stimulates a variety of neurotransmitters, leading to increased intestinal motility and providing protective effects against GI injury. POI is the most common emergent complication following abdominal and pelvic surgery, and is characterized by postoperative bowel dysfunction, pain, and inflammatory responses. It is noteworthy that natural herbs are gradually gaining recognition as a potential therapeutic option for POI due to the lack of effective pharmacological interventions. Therefore, the focus of this paper is on the TRPV1/TRPA1 channel, and an analysis and summary of the processes and mechanism by which natural herbs activate TRPV1/TRPA1 to enhance GI motility and relieve pain are provided, which will lay the foundation for the development of natural herb treatments for this disease. |
| first_indexed | 2024-03-11T18:31:44Z |
| format | Article |
| id | doaj.art-3a6997f0abc64ba2b44113cb9c11c92e |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-11T18:31:44Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-3a6997f0abc64ba2b44113cb9c11c92e2023-10-13T11:03:40ZengElsevierPharmacological Research1096-11862023-10-01196106923Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileusQi Liang0Jing-Wen Wang1Yu-Ru Bai2Ruo-Lan Li3Chun-Jie Wu4Wei Peng5State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaInstitute of Innovation, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China; Correspondence to: Institute of Innovation, Chengdu University of Traditional Chinese Medicine, No.1166 Liutai Avenue, Chengdu 611137, PR China.State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China; Correspondence to: State Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Chengdu 611137, PR China.Under physiological or pathological conditions, transient receptor potential (TRP) channel vanilloid type 1 (TRPV1) and TRP ankyrin 1 (TRPA1) possess the ability to detect a vast array of stimuli and execute diverse functions. Interestingly, increasing works have reported that activation of TRPV1 and TRPA1 could also be beneficial for ameliorating postoperative ileus (POI). Increasing research has revealed that the gastrointestinal (GI) tract is rich in TRPV1/TRPA1, which can be stimulated by capsaicin, allicin and other compounds. This activation stimulates a variety of neurotransmitters, leading to increased intestinal motility and providing protective effects against GI injury. POI is the most common emergent complication following abdominal and pelvic surgery, and is characterized by postoperative bowel dysfunction, pain, and inflammatory responses. It is noteworthy that natural herbs are gradually gaining recognition as a potential therapeutic option for POI due to the lack of effective pharmacological interventions. Therefore, the focus of this paper is on the TRPV1/TRPA1 channel, and an analysis and summary of the processes and mechanism by which natural herbs activate TRPV1/TRPA1 to enhance GI motility and relieve pain are provided, which will lay the foundation for the development of natural herb treatments for this disease.http://www.sciencedirect.com/science/article/pii/S1043661823002797Postoperative ileusTRPV1TRPA1Natural herbal medicines |
| spellingShingle | Qi Liang Jing-Wen Wang Yu-Ru Bai Ruo-Lan Li Chun-Jie Wu Wei Peng Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileus Pharmacological Research Postoperative ileus TRPV1 TRPA1 Natural herbal medicines |
| title | Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileus |
| title_full | Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileus |
| title_fullStr | Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileus |
| title_full_unstemmed | Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileus |
| title_short | Targeting TRPV1 and TRPA1: A feasible strategy for natural herbal medicines to combat postoperative ileus |
| title_sort | targeting trpv1 and trpa1 a feasible strategy for natural herbal medicines to combat postoperative ileus |
| topic | Postoperative ileus TRPV1 TRPA1 Natural herbal medicines |
| url | http://www.sciencedirect.com/science/article/pii/S1043661823002797 |
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