Advances in Urate Excretion and Urate Transporters in Hyperuricemia
Hyperuricemia is a heterogeneous disease caused by dysregulation of the homeostasis of urate production and excretion, which leads to the elevation of blood uric acid beyond the normal range. It has been found that three common genes ABCG2, SLC2A9 and SLC22A12 have a great influence on serum uric ac...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2023-05-01
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| Series: | Zhongguo quanke yixue |
| Subjects: | |
| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220747.pdf |
| _version_ | 1827289461050834944 |
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| author | XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong |
| author_facet | XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong |
| author_sort | XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong |
| collection | DOAJ |
| description | Hyperuricemia is a heterogeneous disease caused by dysregulation of the homeostasis of urate production and excretion, which leads to the elevation of blood uric acid beyond the normal range. It has been found that three common genes ABCG2, SLC2A9 and SLC22A12 have a great influence on serum uric acid level in human body. Other urate transporter genes, such as SLC16A9, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A11, SLC22A13 and ABCC4 also play a crucial role in the regulation of urate levels. This article reviews the urate transporters mentioned above that have been found to be related to the development of hyperuricemia, including uric acid reabsorption transporter and uric acid secretion transporter in kidney, uric acid transporter in intestine, aiming at providing theoretical and data support for future clinical treatment. |
| first_indexed | 2024-04-24T11:49:57Z |
| format | Article |
| id | doaj.art-3a69f0f9f696438a9e055517db54e5c9 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:49:57Z |
| publishDate | 2023-05-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-3a69f0f9f696438a9e055517db54e5c92024-04-09T07:53:24ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722023-05-0126151916192210.12114/j.issn.1007-9572.2022.0747Advances in Urate Excretion and Urate Transporters in HyperuricemiaXIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong01. Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine1, Shanghai 200120, China;2. TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China;3. Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 200000, China;4. Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, ChinaHyperuricemia is a heterogeneous disease caused by dysregulation of the homeostasis of urate production and excretion, which leads to the elevation of blood uric acid beyond the normal range. It has been found that three common genes ABCG2, SLC2A9 and SLC22A12 have a great influence on serum uric acid level in human body. Other urate transporter genes, such as SLC16A9, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A11, SLC22A13 and ABCC4 also play a crucial role in the regulation of urate levels. This article reviews the urate transporters mentioned above that have been found to be related to the development of hyperuricemia, including uric acid reabsorption transporter and uric acid secretion transporter in kidney, uric acid transporter in intestine, aiming at providing theoretical and data support for future clinical treatment.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220747.pdfhyperuricemia|uric acid|uric acid transporter|gene expression|review |
| spellingShingle | XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong Advances in Urate Excretion and Urate Transporters in Hyperuricemia Zhongguo quanke yixue hyperuricemia|uric acid|uric acid transporter|gene expression|review |
| title | Advances in Urate Excretion and Urate Transporters in Hyperuricemia |
| title_full | Advances in Urate Excretion and Urate Transporters in Hyperuricemia |
| title_fullStr | Advances in Urate Excretion and Urate Transporters in Hyperuricemia |
| title_full_unstemmed | Advances in Urate Excretion and Urate Transporters in Hyperuricemia |
| title_short | Advances in Urate Excretion and Urate Transporters in Hyperuricemia |
| title_sort | advances in urate excretion and urate transporters in hyperuricemia |
| topic | hyperuricemia|uric acid|uric acid transporter|gene expression|review |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220747.pdf |
| work_keys_str_mv | AT xinjiadongzhoujiabaowuzhiyuanzhangxuminggaojiandong advancesinurateexcretionanduratetransportersinhyperuricemia |