Tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancer
Neoadjuvant therapy has been widely employed in the treatment of rectal cancer, demonstrating its utility in reducing tumor volume, downstaging tumors, and improving patient prognosis. It has become the standard preoperative treatment modality for locally advanced rectal cancer. However, the efficac...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1375334/full |
| _version_ | 1797224255711084544 |
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| author | Guilin Yu Huanyu Chi Huanyu Chi Guohua Zhao Yue Wang |
| author_facet | Guilin Yu Huanyu Chi Huanyu Chi Guohua Zhao Yue Wang |
| author_sort | Guilin Yu |
| collection | DOAJ |
| description | Neoadjuvant therapy has been widely employed in the treatment of rectal cancer, demonstrating its utility in reducing tumor volume, downstaging tumors, and improving patient prognosis. It has become the standard preoperative treatment modality for locally advanced rectal cancer. However, the efficacy of neoadjuvant therapy varies significantly among patients, with notable differences in tumor regression outcomes. In some cases, patients exhibit substantial tumor regression, even achieving pathological complete response. The assessment of tumor regression outcomes holds crucial significance for determining surgical approaches and establishing safe margins. Nonetheless, current research on tumor regression patterns remains limited, and there is considerable controversy surrounding the determination of a safe margin after neoadjuvant therapy. In light of these factors, this study aims to summarize the primary patterns of tumor regression observed following neoadjuvant therapy for rectal cancer, categorizing them into three types: tumor shrinkage, tumor fragmentation, and mucinous lake formation. Furthermore, a comparison will be made between gross and microscopic tumor regression, highlighting the asynchronous nature of regression in the two contexts. Additionally, this study will analyze the safety of non-surgical treatment in patients who achieve complete clinical response, elucidating the necessity of surgical intervention. Lastly, the study will investigate the optimal range for safe surgical resection margins and explore the concept of a safe margin distance post-neoadjuvant therapy. |
| first_indexed | 2024-04-24T13:50:13Z |
| format | Article |
| id | doaj.art-3a6e581120414c76b441f479dbbaa5bd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T13:50:13Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3a6e581120414c76b441f479dbbaa5bd2024-04-04T05:04:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.13753341375334Tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancerGuilin Yu0Huanyu Chi1Huanyu Chi2Guohua Zhao3Yue Wang4Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, ChinaDepartment of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, ChinaThe Second Clinical College, Dalian Medical University, Dalian, ChinaDepartment of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, ChinaDepartment of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, ChinaNeoadjuvant therapy has been widely employed in the treatment of rectal cancer, demonstrating its utility in reducing tumor volume, downstaging tumors, and improving patient prognosis. It has become the standard preoperative treatment modality for locally advanced rectal cancer. However, the efficacy of neoadjuvant therapy varies significantly among patients, with notable differences in tumor regression outcomes. In some cases, patients exhibit substantial tumor regression, even achieving pathological complete response. The assessment of tumor regression outcomes holds crucial significance for determining surgical approaches and establishing safe margins. Nonetheless, current research on tumor regression patterns remains limited, and there is considerable controversy surrounding the determination of a safe margin after neoadjuvant therapy. In light of these factors, this study aims to summarize the primary patterns of tumor regression observed following neoadjuvant therapy for rectal cancer, categorizing them into three types: tumor shrinkage, tumor fragmentation, and mucinous lake formation. Furthermore, a comparison will be made between gross and microscopic tumor regression, highlighting the asynchronous nature of regression in the two contexts. Additionally, this study will analyze the safety of non-surgical treatment in patients who achieve complete clinical response, elucidating the necessity of surgical intervention. Lastly, the study will investigate the optimal range for safe surgical resection margins and explore the concept of a safe margin distance post-neoadjuvant therapy.https://www.frontiersin.org/articles/10.3389/fonc.2024.1375334/fullrectal tumorneoadjuvant therapydistal resection margintumor regressionsafe distance |
| spellingShingle | Guilin Yu Huanyu Chi Huanyu Chi Guohua Zhao Yue Wang Tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancer Frontiers in Oncology rectal tumor neoadjuvant therapy distal resection margin tumor regression safe distance |
| title | Tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancer |
| title_full | Tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancer |
| title_fullStr | Tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancer |
| title_full_unstemmed | Tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancer |
| title_short | Tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancer |
| title_sort | tumor regression and safe distance of distal margin after neoadjuvant therapy for rectal cancer |
| topic | rectal tumor neoadjuvant therapy distal resection margin tumor regression safe distance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1375334/full |
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