How sequence alterations enhance the stability and delay expansion of DNA triplet repeat domains

DNA sequence alterations within DNA repeat domains inexplicably enhance the stability and delay the expansion of interrupted repeat domains. Here we propose mechanisms that rationalise such unanticipated outcomes. Specifically, we describe how interruption of a DNA repeat domain restricts the ensemb...

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Bibliographic Details
Main Authors: Jens Völker, Kenneth J. Breslauer
Format: Article
Language:English
Published: Cambridge University Press 2023-01-01
Series:QRB Discovery
Subjects:
Online Access:https://www.cambridge.org/core/product/identifier/S2633289223000066/type/journal_article