Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agents
Magnetic nanoparticles (MNPs) are widely applied in antibacterial therapy owing to their distinct nanoscale structure, intrinsic peroxidase-like activities, and magnetic behavior. However, some deficiencies, such as the tendency to aggregate in water, unsatisfactory biocompatibility, and limited ant...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1184592/full |
| _version_ | 1797850962077941760 |
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| author | Yuying Jiang Yuying Jiang Xinkai Xu Xinkai Xu Jinglin Lu Jinglin Lu Chuqiang Yin Guotai Li Longjian Bai Longjian Bai Tiantian Zhang Tiantian Zhang Jianning Mo Jianning Mo Xiaoyu Wang Xiaoyu Wang Qiang Shi Ting Wang Qihui Zhou Qihui Zhou Qihui Zhou |
| author_facet | Yuying Jiang Yuying Jiang Xinkai Xu Xinkai Xu Jinglin Lu Jinglin Lu Chuqiang Yin Guotai Li Longjian Bai Longjian Bai Tiantian Zhang Tiantian Zhang Jianning Mo Jianning Mo Xiaoyu Wang Xiaoyu Wang Qiang Shi Ting Wang Qihui Zhou Qihui Zhou Qihui Zhou |
| author_sort | Yuying Jiang |
| collection | DOAJ |
| description | Magnetic nanoparticles (MNPs) are widely applied in antibacterial therapy owing to their distinct nanoscale structure, intrinsic peroxidase-like activities, and magnetic behavior. However, some deficiencies, such as the tendency to aggregate in water, unsatisfactory biocompatibility, and limited antibacterial effect, hindered their further clinical applications. Surface modification of MNPs is one of the main strategies to improve their (bio)physicochemical properties and enhance biological functions. Herein, antibacterial ε-poly (L-lysine) carbon dots (PL-CDs) modified MNPs (CMNPs) were synthesized to investigate their performance in eliminating pathogenic bacteria. It was found that the PL-CDs were successfully loaded on the surface of MNPs by detecting their morphology, surface charges, functional groups, and other physicochemical properties. The positively charged CMNPs show superparamagnetic properties and are well dispersed in water. Furthermore, bacterial experiments indicate that the CMNPs exhibited highly effective antimicrobial properties against Staphylococcus aureus. Notably, the in vitro cellular assays show that CMNPs have favorable cytocompatibility. Thus, CMNPs acting as novel smart nanomaterials could offer great potential for the clinical treatment of bacterial infections. |
| first_indexed | 2024-04-09T19:09:01Z |
| format | Article |
| id | doaj.art-3a709c269fb4405490536ff902fce4e8 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-09T19:09:01Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-3a709c269fb4405490536ff902fce4e82023-04-07T04:31:16ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-04-011110.3389/fchem.2023.11845921184592Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agentsYuying Jiang0Yuying Jiang1Xinkai Xu2Xinkai Xu3Jinglin Lu4Jinglin Lu5Chuqiang Yin6Guotai Li7Longjian Bai8Longjian Bai9Tiantian Zhang10Tiantian Zhang11Jianning Mo12Jianning Mo13Xiaoyu Wang14Xiaoyu Wang15Qiang Shi16Ting Wang17Qihui Zhou18Qihui Zhou19Qihui Zhou20The Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaThe Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaThe Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaThe Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, ChinaThe Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaThe Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaThe Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaThe Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaMoji-Nano Technology Co. Ltd, Yantai, ChinaThe Affliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, ChinaMoji-Nano Technology Co. Ltd, Yantai, ChinaZhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaMagnetic nanoparticles (MNPs) are widely applied in antibacterial therapy owing to their distinct nanoscale structure, intrinsic peroxidase-like activities, and magnetic behavior. However, some deficiencies, such as the tendency to aggregate in water, unsatisfactory biocompatibility, and limited antibacterial effect, hindered their further clinical applications. Surface modification of MNPs is one of the main strategies to improve their (bio)physicochemical properties and enhance biological functions. Herein, antibacterial ε-poly (L-lysine) carbon dots (PL-CDs) modified MNPs (CMNPs) were synthesized to investigate their performance in eliminating pathogenic bacteria. It was found that the PL-CDs were successfully loaded on the surface of MNPs by detecting their morphology, surface charges, functional groups, and other physicochemical properties. The positively charged CMNPs show superparamagnetic properties and are well dispersed in water. Furthermore, bacterial experiments indicate that the CMNPs exhibited highly effective antimicrobial properties against Staphylococcus aureus. Notably, the in vitro cellular assays show that CMNPs have favorable cytocompatibility. Thus, CMNPs acting as novel smart nanomaterials could offer great potential for the clinical treatment of bacterial infections.https://www.frontiersin.org/articles/10.3389/fchem.2023.1184592/fullmagnetic nanoparticlescarbon dotsantibacteriasmart nanomaterialscytocompatibility |
| spellingShingle | Yuying Jiang Yuying Jiang Xinkai Xu Xinkai Xu Jinglin Lu Jinglin Lu Chuqiang Yin Guotai Li Longjian Bai Longjian Bai Tiantian Zhang Tiantian Zhang Jianning Mo Jianning Mo Xiaoyu Wang Xiaoyu Wang Qiang Shi Ting Wang Qihui Zhou Qihui Zhou Qihui Zhou Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agents Frontiers in Chemistry magnetic nanoparticles carbon dots antibacteria smart nanomaterials cytocompatibility |
| title | Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agents |
| title_full | Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agents |
| title_fullStr | Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agents |
| title_full_unstemmed | Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agents |
| title_short | Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agents |
| title_sort | development of ε poly l lysine carbon dots modified magnetic nanoparticles and their applications as novel antibacterial agents |
| topic | magnetic nanoparticles carbon dots antibacteria smart nanomaterials cytocompatibility |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1184592/full |
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