Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patients
Abstract Background Although global longitudinal strain (GLS) is proven to be reduced and associated with adverse outcomes in septic patients, it has not been elucidated whether or not layer-specific strains are reduced. We aimed to explore the layer-specific strains of left ventricular (LV) for ass...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-023-02186-x |
| _version_ | 1797556916373684224 |
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| author | Jin Zhang Jing Zhu Tian Xie Fan Sun Ni Wang Feng-Mei Guo |
| author_facet | Jin Zhang Jing Zhu Tian Xie Fan Sun Ni Wang Feng-Mei Guo |
| author_sort | Jin Zhang |
| collection | DOAJ |
| description | Abstract Background Although global longitudinal strain (GLS) is proven to be reduced and associated with adverse outcomes in septic patients, it has not been elucidated whether or not layer-specific strains are reduced. We aimed to explore the layer-specific strains of left ventricular (LV) for assessing myocardial dysfunction in septic patients. Methods A prospective observational study of patients with sepsis was conducted in a tertiary hospital in China. Routine two-dimensional speckle tracking echocardiography was performed within 24 h of enrollment. Demographic data, laboratory values, and clinical outcomes were collected. Results We recruited 79 septic patients finally. The mean age of septic patients was 59.4 years old and 45 (57.0%) were male. The median Acute Physiology Age and Chronic Health Evaluation (APACHE II) score, and mean sequential organ failure assessment (SOFA) score of all patients were 19.0 and 7.7, respectively. According to the left ventricular ejection fraction (LVEF) value of 50%, the patients were categorized into two groups: SICM (sepsis-induced cardiomyopathy, LVEF < 50%, n = 22) and non-SICM group ( LVEF ≥ 50%, n = 57). The median LVEF of SICM and non-SICM patients were 41.9% and 58.7%, and SICM patients had less negative layer-specific strain and global strain than that of non-SICM patients. The echocardiographic comparison of non-SICM and healthy controls was conducted to explore the myocardial injuries of non-SICM patients and the non-SICM had worse LS-epi than that of controls (-18.5% vs. -21.4%, p = 0.024). Conclusion There were 72.2% (57) septic patients presented with non-SICM (LVEF ≥ 50%), and the strain value of epicardium of them was less negative than healthy controls. |
| first_indexed | 2024-03-10T17:09:47Z |
| format | Article |
| id | doaj.art-3a71fee14ae845e38a4fee9dacdbe9dd |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-03-10T17:09:47Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-3a71fee14ae845e38a4fee9dacdbe9dd2023-11-20T10:41:54ZengBMCBMC Anesthesiology1471-22532023-08-012311810.1186/s12871-023-02186-xQuantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patientsJin Zhang0Jing Zhu1Tian Xie2Fan Sun3Ni Wang4Feng-Mei Guo5Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast UniversityDepartment of Cardiology, The Second Affiliated Hospital of Soochow UniversityJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast UniversityJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast UniversityJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast UniversityJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast UniversityAbstract Background Although global longitudinal strain (GLS) is proven to be reduced and associated with adverse outcomes in septic patients, it has not been elucidated whether or not layer-specific strains are reduced. We aimed to explore the layer-specific strains of left ventricular (LV) for assessing myocardial dysfunction in septic patients. Methods A prospective observational study of patients with sepsis was conducted in a tertiary hospital in China. Routine two-dimensional speckle tracking echocardiography was performed within 24 h of enrollment. Demographic data, laboratory values, and clinical outcomes were collected. Results We recruited 79 septic patients finally. The mean age of septic patients was 59.4 years old and 45 (57.0%) were male. The median Acute Physiology Age and Chronic Health Evaluation (APACHE II) score, and mean sequential organ failure assessment (SOFA) score of all patients were 19.0 and 7.7, respectively. According to the left ventricular ejection fraction (LVEF) value of 50%, the patients were categorized into two groups: SICM (sepsis-induced cardiomyopathy, LVEF < 50%, n = 22) and non-SICM group ( LVEF ≥ 50%, n = 57). The median LVEF of SICM and non-SICM patients were 41.9% and 58.7%, and SICM patients had less negative layer-specific strain and global strain than that of non-SICM patients. The echocardiographic comparison of non-SICM and healthy controls was conducted to explore the myocardial injuries of non-SICM patients and the non-SICM had worse LS-epi than that of controls (-18.5% vs. -21.4%, p = 0.024). Conclusion There were 72.2% (57) septic patients presented with non-SICM (LVEF ≥ 50%), and the strain value of epicardium of them was less negative than healthy controls.https://doi.org/10.1186/s12871-023-02186-xSepsisGLSLayer-specific strainLeft ventricular, Sepsis-induced cardiomyopathy |
| spellingShingle | Jin Zhang Jing Zhu Tian Xie Fan Sun Ni Wang Feng-Mei Guo Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patients BMC Anesthesiology Sepsis GLS Layer-specific strain Left ventricular, Sepsis-induced cardiomyopathy |
| title | Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patients |
| title_full | Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patients |
| title_fullStr | Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patients |
| title_full_unstemmed | Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patients |
| title_short | Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patients |
| title_sort | quantitative evaluation of myocardial layer specific strain using two dimensional speckle tracking echocardiography in septic patients |
| topic | Sepsis GLS Layer-specific strain Left ventricular, Sepsis-induced cardiomyopathy |
| url | https://doi.org/10.1186/s12871-023-02186-x |
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