The Efficacy of Voluven vs. Albumin Infusion in Prevention and Treatment of Clinical Vasospasm following Subarachnoid Hemorrhage
Background: Clinical vasospasm following subarachnoid hemorrhage is one of the most important causes of mortality during first two weeks after subarachnoid hemorrhage. Thus, some investigations have been conducted to evaluate the efficacy of triple-H accompanied with other drugs, such as calcium blo...
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Isfahan University of Medical Sciences
2012-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1098 |
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| author | Mohammad Ali Attari Mohammad Hadizadeh Massih Saboori Mahnaz Moradi |
| author_facet | Mohammad Ali Attari Mohammad Hadizadeh Massih Saboori Mahnaz Moradi |
| author_sort | Mohammad Ali Attari |
| collection | DOAJ |
| description | Background: Clinical vasospasm following subarachnoid hemorrhage is one of the most important causes of mortality during first two weeks after subarachnoid hemorrhage. Thus, some investigations have been conducted to evaluate the efficacy of triple-H accompanied with other drugs, such as calcium blocker, and early operation. In addition, colloid solutions such as albumin have also been used in treatment of hypervolemia. However, no study has compared different liquids. The aim of this study was to evaluate the efficacy of Voluven vs. albumin infusion (as hyper volume therapy) in prevention and treatment of clinical vasospasm following subarachnoid hemorrhage.
Methods: This double-blind clinical trial that was performed in Alzahra Hospital, Isfahan, Iran, in 2011. We studied 64 patients with aneurysm, subarachnoid hemorrhage who referred to the hospital. The patients were divided into two groups. Early surgery was performed whenever possible and hypertensive hypervolemic hemodilution therapy was instituted with the first sign of clinical vasospasm. The first group was treated by albumin and the second group by Voluven liquids. Both groups were followed-up for 2 weeks. Glasgow Coma Scale (GCS) and Hunt-Hess Grade (HHG) were used for daily assessments of neurologic status, neurologic deficit, and hemodynamic status of the patients. Finally, the collected data was analyzed by SPSS.
Findings: According to the results of this study, no statistically significant differences in the trend of GCS and HHG were observed between the two groups during follow-up (P > 0.05).
Conclusion: There were not any significant differences between the two groups in terms of treatment results and complications. However, Voluven is cheaper than albumin. Therefore, Voluven can be efficiently used for prevention and treatment of clinical vasospasm following subarachnoid hemorrhage. |
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| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:53:40Z |
| publishDate | 2012-03-01 |
| publisher | Isfahan University of Medical Sciences |
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| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-3a735231055240a4ba88e9da17812abf2023-09-02T16:11:37ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-03-012916320182025947The Efficacy of Voluven vs. Albumin Infusion in Prevention and Treatment of Clinical Vasospasm following Subarachnoid HemorrhageMohammad Ali Attari0Mohammad Hadizadeh1Massih Saboori2Mahnaz Moradi3Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranResident, Department of Anesthesiology, School of Medicine And Student Research committee, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Neurosurgery , School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranResident, Department of Internal Medicine, School of Medicine And Student Research committee, Isfahan University of Medical Sciences, Isfahan, IranBackground: Clinical vasospasm following subarachnoid hemorrhage is one of the most important causes of mortality during first two weeks after subarachnoid hemorrhage. Thus, some investigations have been conducted to evaluate the efficacy of triple-H accompanied with other drugs, such as calcium blocker, and early operation. In addition, colloid solutions such as albumin have also been used in treatment of hypervolemia. However, no study has compared different liquids. The aim of this study was to evaluate the efficacy of Voluven vs. albumin infusion (as hyper volume therapy) in prevention and treatment of clinical vasospasm following subarachnoid hemorrhage. Methods: This double-blind clinical trial that was performed in Alzahra Hospital, Isfahan, Iran, in 2011. We studied 64 patients with aneurysm, subarachnoid hemorrhage who referred to the hospital. The patients were divided into two groups. Early surgery was performed whenever possible and hypertensive hypervolemic hemodilution therapy was instituted with the first sign of clinical vasospasm. The first group was treated by albumin and the second group by Voluven liquids. Both groups were followed-up for 2 weeks. Glasgow Coma Scale (GCS) and Hunt-Hess Grade (HHG) were used for daily assessments of neurologic status, neurologic deficit, and hemodynamic status of the patients. Finally, the collected data was analyzed by SPSS. Findings: According to the results of this study, no statistically significant differences in the trend of GCS and HHG were observed between the two groups during follow-up (P > 0.05). Conclusion: There were not any significant differences between the two groups in terms of treatment results and complications. However, Voluven is cheaper than albumin. Therefore, Voluven can be efficiently used for prevention and treatment of clinical vasospasm following subarachnoid hemorrhage.http://jims.mui.ac.ir/index.php/jims/article/view/1098VoluvenAlbuminVasospasmSubarachnoid hemorrhage |
| spellingShingle | Mohammad Ali Attari Mohammad Hadizadeh Massih Saboori Mahnaz Moradi The Efficacy of Voluven vs. Albumin Infusion in Prevention and Treatment of Clinical Vasospasm following Subarachnoid Hemorrhage مجله دانشکده پزشکی اصفهان Voluven Albumin Vasospasm Subarachnoid hemorrhage |
| title | The Efficacy of Voluven vs. Albumin Infusion in Prevention and Treatment of Clinical Vasospasm following Subarachnoid Hemorrhage |
| title_full | The Efficacy of Voluven vs. Albumin Infusion in Prevention and Treatment of Clinical Vasospasm following Subarachnoid Hemorrhage |
| title_fullStr | The Efficacy of Voluven vs. Albumin Infusion in Prevention and Treatment of Clinical Vasospasm following Subarachnoid Hemorrhage |
| title_full_unstemmed | The Efficacy of Voluven vs. Albumin Infusion in Prevention and Treatment of Clinical Vasospasm following Subarachnoid Hemorrhage |
| title_short | The Efficacy of Voluven vs. Albumin Infusion in Prevention and Treatment of Clinical Vasospasm following Subarachnoid Hemorrhage |
| title_sort | efficacy of voluven vs albumin infusion in prevention and treatment of clinical vasospasm following subarachnoid hemorrhage |
| topic | Voluven Albumin Vasospasm Subarachnoid hemorrhage |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/1098 |
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