Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the p<i>K</i>a and the pH-solubility profile were experimentally determined....

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Bibliographic Details
Main Authors: Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Alex Avdeef, Miguel-Ángel Cabrera-Pérez
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
intestinal permeability
Caco-2
solubility-pH
p<i>K</i>a
BCS
JM-20
Online Access:https://www.mdpi.com/1999-4923/14/1/182

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