Polar lipids modify Alzheimer’s Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation

Polar lipids modify Alzheimer’s Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation

Abstract Background Pro-inflammatory processes triggered by the accumulation of extracellular amyloid beta (Aβ) peptides are a well-described pathology in Alzheimer's disease (AD). Activated astrocytes surrounding Aβ plaques contribute to inflammation by secreting proinflammatory factors. While...

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Bibliographic Details
Main Authors: Sakshi Hans, Janelle E. Stanton, Ann Katrin Sauer, Katie Shiels, Sushanta Kumar Saha, Ronan Lordan, Alexandros Tsoupras, Ioannis Zabetakis, Andreas M. Grabrucker
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Lipids in Health and Disease
Subjects:
Polar lipids
Alzheimer's Disease
Beta-amyloid
Neuroinflammation
Nutrition
Astrocytes
Online Access:https://doi.org/10.1186/s12944-024-02106-z

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