Glioma-on-a-Chip Models
Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months). Glioma-on-chip platforms, with continuous perfusion, mimic in vivo m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/5/490 |
| _version_ | 1797536167188496384 |
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| author | Merve Ustun Sajjad Rahmani Dabbagh Irem Sultan Ilci Tugba Bagci-Onder Savas Tasoglu |
| author_facet | Merve Ustun Sajjad Rahmani Dabbagh Irem Sultan Ilci Tugba Bagci-Onder Savas Tasoglu |
| author_sort | Merve Ustun |
| collection | DOAJ |
| description | Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months). Glioma-on-chip platforms, with continuous perfusion, mimic in vivo metabolic functions of cancer cells for analytical purposes. This offers an unprecedented opportunity for understanding the underlying reasons that arise glioma, determining the most effective radiotherapy approach, testing different drug combinations, and screening conceivable side effects of drugs on other organs. Glioma-on-chip technologies can ultimately enhance the efficacy of treatments, promote the survival rate of patients, and pave a path for personalized medicine. In this perspective paper, we briefly review the latest developments of glioma-on-chip technologies, such as therapy applications, drug screening, and cell behavior studies, and discuss the current challenges as well as future research directions in this field. |
| first_indexed | 2024-03-10T11:55:48Z |
| format | Article |
| id | doaj.art-3a7534b69807430f909841554220c2ed |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T11:55:48Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-3a7534b69807430f909841554220c2ed2023-11-21T17:16:24ZengMDPI AGMicromachines2072-666X2021-04-0112549010.3390/mi12050490Glioma-on-a-Chip ModelsMerve Ustun0Sajjad Rahmani Dabbagh1Irem Sultan Ilci2Tugba Bagci-Onder3Savas Tasoglu4Graduate School of Sciences and Engineering, Koc University, Sariyer, 34450 Istanbul, TurkeyDepartment of Mechanical Engineering, Koç University, Sariyer, 34450 Istanbul, TurkeyDepartment of Bioengineering, Yildiz Technical University, 34220 Istanbul, TurkeyBrain Cancer Research and Therapy Lab, Koç University School of Medicine, 34450 Istanbul, TurkeyDepartment of Mechanical Engineering, Koç University, Sariyer, 34450 Istanbul, TurkeyGlioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months). Glioma-on-chip platforms, with continuous perfusion, mimic in vivo metabolic functions of cancer cells for analytical purposes. This offers an unprecedented opportunity for understanding the underlying reasons that arise glioma, determining the most effective radiotherapy approach, testing different drug combinations, and screening conceivable side effects of drugs on other organs. Glioma-on-chip technologies can ultimately enhance the efficacy of treatments, promote the survival rate of patients, and pave a path for personalized medicine. In this perspective paper, we briefly review the latest developments of glioma-on-chip technologies, such as therapy applications, drug screening, and cell behavior studies, and discuss the current challenges as well as future research directions in this field.https://www.mdpi.com/2072-666X/12/5/490organ-on-a-chipgliomabraintissue-on-a-chipdisease-on-a-chiptumor-on-a-chip |
| spellingShingle | Merve Ustun Sajjad Rahmani Dabbagh Irem Sultan Ilci Tugba Bagci-Onder Savas Tasoglu Glioma-on-a-Chip Models Micromachines organ-on-a-chip glioma brain tissue-on-a-chip disease-on-a-chip tumor-on-a-chip |
| title | Glioma-on-a-Chip Models |
| title_full | Glioma-on-a-Chip Models |
| title_fullStr | Glioma-on-a-Chip Models |
| title_full_unstemmed | Glioma-on-a-Chip Models |
| title_short | Glioma-on-a-Chip Models |
| title_sort | glioma on a chip models |
| topic | organ-on-a-chip glioma brain tissue-on-a-chip disease-on-a-chip tumor-on-a-chip |
| url | https://www.mdpi.com/2072-666X/12/5/490 |
| work_keys_str_mv | AT merveustun gliomaonachipmodels AT sajjadrahmanidabbagh gliomaonachipmodels AT iremsultanilci gliomaonachipmodels AT tugbabagcionder gliomaonachipmodels AT savastasoglu gliomaonachipmodels |