A link between mitotic defects and mitotic catastrophe: detection and cell fate
Abstract Although the phenomenon of mitotic catastrophe was first described more than 80 years ago, only recently has this term been used to explain a mechanism of cell death linked to delayed mitosis. Several mechanisms have been suggested for mitotic catastrophe development and cell fate. Dependin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Biology Direct |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13062-021-00313-7 |
| _version_ | 1818383714231517184 |
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| author | Elena V. Sazonova Svetlana V. Petrichuk Gelina S. Kopeina Boris Zhivotovsky |
| author_facet | Elena V. Sazonova Svetlana V. Petrichuk Gelina S. Kopeina Boris Zhivotovsky |
| author_sort | Elena V. Sazonova |
| collection | DOAJ |
| description | Abstract Although the phenomenon of mitotic catastrophe was first described more than 80 years ago, only recently has this term been used to explain a mechanism of cell death linked to delayed mitosis. Several mechanisms have been suggested for mitotic catastrophe development and cell fate. Depending on molecular perturbations, mitotic catastrophe can end in three types of cell death, namely apoptosis, necrosis, or autophagy. Moreover, mitotic catastrophe can be associated with different types of cell aging, the development of which negatively affects tumor elimination and, consequently, reduces the therapeutic effect. The effective triggering of mitotic catastrophe in clinical practice requires induction of DNA damage as well as inhibition of the molecular pathways that regulate cell cycle arrest and DNA repair. Here we discuss various methods to detect mitotic catastrophe, the mechanisms of its development, and the attempts to use this phenomenon in cancer treatment. |
| first_indexed | 2024-12-14T03:10:45Z |
| format | Article |
| id | doaj.art-3a76a226034a4270bb8aa44be03b9aea |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-12-14T03:10:45Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-3a76a226034a4270bb8aa44be03b9aea2022-12-21T23:19:16ZengBMCBiology Direct1745-61502021-12-0116111110.1186/s13062-021-00313-7A link between mitotic defects and mitotic catastrophe: detection and cell fateElena V. Sazonova0Svetlana V. Petrichuk1Gelina S. Kopeina2Boris Zhivotovsky3Faculty of Medicine, MV Lomonosov Moscow State UniversityFederal State Autonomous Institution “National Medical Research Center for Children’s Health” of the Ministry of Health of the Russian FederationFaculty of Medicine, MV Lomonosov Moscow State UniversityFaculty of Medicine, MV Lomonosov Moscow State UniversityAbstract Although the phenomenon of mitotic catastrophe was first described more than 80 years ago, only recently has this term been used to explain a mechanism of cell death linked to delayed mitosis. Several mechanisms have been suggested for mitotic catastrophe development and cell fate. Depending on molecular perturbations, mitotic catastrophe can end in three types of cell death, namely apoptosis, necrosis, or autophagy. Moreover, mitotic catastrophe can be associated with different types of cell aging, the development of which negatively affects tumor elimination and, consequently, reduces the therapeutic effect. The effective triggering of mitotic catastrophe in clinical practice requires induction of DNA damage as well as inhibition of the molecular pathways that regulate cell cycle arrest and DNA repair. Here we discuss various methods to detect mitotic catastrophe, the mechanisms of its development, and the attempts to use this phenomenon in cancer treatment.https://doi.org/10.1186/s13062-021-00313-7Mitotic catastropheCell deathSenescenceDNA damageCancer |
| spellingShingle | Elena V. Sazonova Svetlana V. Petrichuk Gelina S. Kopeina Boris Zhivotovsky A link between mitotic defects and mitotic catastrophe: detection and cell fate Biology Direct Mitotic catastrophe Cell death Senescence DNA damage Cancer |
| title | A link between mitotic defects and mitotic catastrophe: detection and cell fate |
| title_full | A link between mitotic defects and mitotic catastrophe: detection and cell fate |
| title_fullStr | A link between mitotic defects and mitotic catastrophe: detection and cell fate |
| title_full_unstemmed | A link between mitotic defects and mitotic catastrophe: detection and cell fate |
| title_short | A link between mitotic defects and mitotic catastrophe: detection and cell fate |
| title_sort | link between mitotic defects and mitotic catastrophe detection and cell fate |
| topic | Mitotic catastrophe Cell death Senescence DNA damage Cancer |
| url | https://doi.org/10.1186/s13062-021-00313-7 |
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