Autoantibodies in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death worldwide, is characterized by irreversible airflow limitation based on obstructive bronchiolitis, emphysema, and chronic pulmonary inflammation. Inhaled toxic gases and particles, e.g., cigarette smoke, are major etiolo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00066/full |
| _version_ | 1818572963114385408 |
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| author | Lifang Wen Susanne Krauss-Etschmann Susanne Krauss-Etschmann Frank Petersen Xinhua Yu Xinhua Yu |
| author_facet | Lifang Wen Susanne Krauss-Etschmann Susanne Krauss-Etschmann Frank Petersen Xinhua Yu Xinhua Yu |
| author_sort | Lifang Wen |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death worldwide, is characterized by irreversible airflow limitation based on obstructive bronchiolitis, emphysema, and chronic pulmonary inflammation. Inhaled toxic gases and particles, e.g., cigarette smoke, are major etiologic factors for COPD, while the pathogenesis of the disease is only partially understood. Over the past decade, an increasing body of evidence has been accumulated for a link between COPD and autoimmunity. Studies with clinical samples have demonstrated that autoantibodies are present in sera of COPD patients and some of these antibodies correlate with specific disease phenotypes. Furthermore, evidence from animal models of COPD has shown that autoimmunity against pulmonary antigens occur during disease development and is capable of mediating COPD-like symptoms. The idea that autoimmunity could contribute to the development of COPD provides a new angle to understand the pathogenesis of the disease. In this review article, we provide an advanced overview in this field and critically discuss the role of autoantibodies in the pathogenesis of COPD. |
| first_indexed | 2024-12-15T00:04:40Z |
| format | Article |
| id | doaj.art-3a775db167234e419f0e45288f5772dd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-15T00:04:40Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3a775db167234e419f0e45288f5772dd2022-12-21T22:42:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-01-01910.3389/fimmu.2018.00066323536Autoantibodies in Chronic Obstructive Pulmonary DiseaseLifang Wen0Susanne Krauss-Etschmann1Susanne Krauss-Etschmann2Frank Petersen3Xinhua Yu4Xinhua Yu5Xiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiamen, ChinaPriority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, GermanyInstitute of Experimental Medicine, Christian-Albrechts-University of Kiel, Kiel, GermanyPriority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, GermanyXiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiamen, ChinaPriority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, GermanyChronic obstructive pulmonary disease (COPD), the fourth leading cause of death worldwide, is characterized by irreversible airflow limitation based on obstructive bronchiolitis, emphysema, and chronic pulmonary inflammation. Inhaled toxic gases and particles, e.g., cigarette smoke, are major etiologic factors for COPD, while the pathogenesis of the disease is only partially understood. Over the past decade, an increasing body of evidence has been accumulated for a link between COPD and autoimmunity. Studies with clinical samples have demonstrated that autoantibodies are present in sera of COPD patients and some of these antibodies correlate with specific disease phenotypes. Furthermore, evidence from animal models of COPD has shown that autoimmunity against pulmonary antigens occur during disease development and is capable of mediating COPD-like symptoms. The idea that autoimmunity could contribute to the development of COPD provides a new angle to understand the pathogenesis of the disease. In this review article, we provide an advanced overview in this field and critically discuss the role of autoantibodies in the pathogenesis of COPD.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00066/fullautoimmunityautoantibodieschronic obstructive pulmonary diseasebiomarkersemphysemaexperimental models |
| spellingShingle | Lifang Wen Susanne Krauss-Etschmann Susanne Krauss-Etschmann Frank Petersen Xinhua Yu Xinhua Yu Autoantibodies in Chronic Obstructive Pulmonary Disease Frontiers in Immunology autoimmunity autoantibodies chronic obstructive pulmonary disease biomarkers emphysema experimental models |
| title | Autoantibodies in Chronic Obstructive Pulmonary Disease |
| title_full | Autoantibodies in Chronic Obstructive Pulmonary Disease |
| title_fullStr | Autoantibodies in Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Autoantibodies in Chronic Obstructive Pulmonary Disease |
| title_short | Autoantibodies in Chronic Obstructive Pulmonary Disease |
| title_sort | autoantibodies in chronic obstructive pulmonary disease |
| topic | autoimmunity autoantibodies chronic obstructive pulmonary disease biomarkers emphysema experimental models |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00066/full |
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