Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses
Siqi Xu,* Huide Zhu,* Zhiwei Zheng Department of Pharmacy, Cancer Hospital of Shantou University Medical College, Shantou, 515041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiwei Zheng, Email zhiweizheng@126.comBackground: This...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-07-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/preoperative-prognostic-nutritional-index-predict-survival-in-patients-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1797785570211004416 |
|---|---|
| author | Xu S Zhu H Zheng Z |
| author_facet | Xu S Zhu H Zheng Z |
| author_sort | Xu S |
| collection | DOAJ |
| description | Siqi Xu,* Huide Zhu,* Zhiwei Zheng Department of Pharmacy, Cancer Hospital of Shantou University Medical College, Shantou, 515041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiwei Zheng, Email zhiweizheng@126.comBackground: This study evaluated the value of PNI to predicting relapse-free survival (RFS) and overall survival (OS) in patients with resectable gastroesophageal junction adenocarcinoma (AGE).Methods: Between 2016 and 2020, there were 236 resectable AGE patients underwent a retrospective review via propensity score matched (PSM) analysis. The PNI values were computed for each patient prior to surgery [PNI= 10×albumin (gr/dL) + 0.005×total lymphocyte count (mm3)]. By using disease progression and mortality as the end points, a receiver operating characteristic(ROC) curve was plotted to identify the PNI cut-off value. Kaplan-Meier curves and Cox proportional hazard models were used for survival analysis.Results: The ROC curve indicated that the ideal cutoff value was 45.60. After propensity score matching, there were 143 patients in our retrospective study, which included 58 patients in the low-PNI group and 85 patients in the high-PNI group. When compared to the low PNI group, the high PNI group substantially increased RFS and OS (p< 0.001, p=0.003, respectively) according to the Kaplan-Meier analysis and Log rank test. Advanced pathological N stage (p=0.011) and poor PNI (p=0.004) were also significant risk factors for a shorter OS, according to a univariate analysis. Multivariate analysis revealed that the N0 plus N1 group had an endpoint mortality risk that was 0.39 times lower than the N2 plus N3 group’s (p=0.008). In comparison to the high PNI group, the hazard of endpoint mortality was 2.442 times greater in the low PNI group (p = 0.003).Conclusion: PNI is a simplistic and practical predictive predictor of the RFS and OS time in patients with resectable AGE.Keywords: prognostic nutritional index, resectable adenocarcinoma esophagogastric junction cancer, relapse-free survival, overall survival, prognosis |
| first_indexed | 2024-03-13T00:56:54Z |
| format | Article |
| id | doaj.art-3a7a7401c28f40bb90ab2fa3fe395c37 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-03-13T00:56:54Z |
| publishDate | 2023-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-3a7a7401c28f40bb90ab2fa3fe395c372023-07-06T19:09:57ZengDove Medical PressCancer Management and Research1179-13222023-07-01Volume 1559159984934Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching AnalysesXu SZhu HZheng ZSiqi Xu,* Huide Zhu,* Zhiwei Zheng Department of Pharmacy, Cancer Hospital of Shantou University Medical College, Shantou, 515041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiwei Zheng, Email zhiweizheng@126.comBackground: This study evaluated the value of PNI to predicting relapse-free survival (RFS) and overall survival (OS) in patients with resectable gastroesophageal junction adenocarcinoma (AGE).Methods: Between 2016 and 2020, there were 236 resectable AGE patients underwent a retrospective review via propensity score matched (PSM) analysis. The PNI values were computed for each patient prior to surgery [PNI= 10×albumin (gr/dL) + 0.005×total lymphocyte count (mm3)]. By using disease progression and mortality as the end points, a receiver operating characteristic(ROC) curve was plotted to identify the PNI cut-off value. Kaplan-Meier curves and Cox proportional hazard models were used for survival analysis.Results: The ROC curve indicated that the ideal cutoff value was 45.60. After propensity score matching, there were 143 patients in our retrospective study, which included 58 patients in the low-PNI group and 85 patients in the high-PNI group. When compared to the low PNI group, the high PNI group substantially increased RFS and OS (p< 0.001, p=0.003, respectively) according to the Kaplan-Meier analysis and Log rank test. Advanced pathological N stage (p=0.011) and poor PNI (p=0.004) were also significant risk factors for a shorter OS, according to a univariate analysis. Multivariate analysis revealed that the N0 plus N1 group had an endpoint mortality risk that was 0.39 times lower than the N2 plus N3 group’s (p=0.008). In comparison to the high PNI group, the hazard of endpoint mortality was 2.442 times greater in the low PNI group (p = 0.003).Conclusion: PNI is a simplistic and practical predictive predictor of the RFS and OS time in patients with resectable AGE.Keywords: prognostic nutritional index, resectable adenocarcinoma esophagogastric junction cancer, relapse-free survival, overall survival, prognosishttps://www.dovepress.com/preoperative-prognostic-nutritional-index-predict-survival-in-patients-peer-reviewed-fulltext-article-CMARprognostic nutritional indexresectable adenocarcinoma esophagogastric junction cancerrelapse-free survival ;overall survivalprognosis |
| spellingShingle | Xu S Zhu H Zheng Z Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses Cancer Management and Research prognostic nutritional index resectable adenocarcinoma esophagogastric junction cancer relapse-free survival ;overall survival prognosis |
| title | Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses |
| title_full | Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses |
| title_fullStr | Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses |
| title_full_unstemmed | Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses |
| title_short | Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses |
| title_sort | preoperative prognostic nutritional index predict survival in patients with resectable adenocarcinoma of the gastroesophageal junction a retrospective study based on propensity score matching analyses |
| topic | prognostic nutritional index resectable adenocarcinoma esophagogastric junction cancer relapse-free survival ;overall survival prognosis |
| url | https://www.dovepress.com/preoperative-prognostic-nutritional-index-predict-survival-in-patients-peer-reviewed-fulltext-article-CMAR |
| work_keys_str_mv | AT xus preoperativeprognosticnutritionalindexpredictsurvivalinpatientswithresectableadenocarcinomaofthegastroesophagealjunctionaretrospectivestudybasedonpropensityscorematchinganalyses AT zhuh preoperativeprognosticnutritionalindexpredictsurvivalinpatientswithresectableadenocarcinomaofthegastroesophagealjunctionaretrospectivestudybasedonpropensityscorematchinganalyses AT zhengz preoperativeprognosticnutritionalindexpredictsurvivalinpatientswithresectableadenocarcinomaofthegastroesophagealjunctionaretrospectivestudybasedonpropensityscorematchinganalyses |