Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system

Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system

Microphysiological system (MPS), a new technology for in vitro testing platforms, have been acknowledged as a strong tool for drug development. In the central nervous system (CNS), the blood‒brain barrier (BBB) limits the permeation of circulating substances from the blood vessels to the brain, ther...

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Bibliographic Details
Main Authors: Kimiko Nakayama-Kitamura, Yukari Shigemoto-Mogami, Hiroko Toyoda, Ikue Mihara, Hiroyuki Moriguchi, Hitoshi Naraoka, Tomomi Furihata, Seiichi Ishida, Kaoru Sato
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Regenerative Therapy
Subjects:
Blood‒brain barrier (BBB)
Microphysiological system (MPS)
P-gp
BCRP
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320423000111

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