Estrogen-functionalized liposomes grafted with glutathione-responsive sheddable chotooligosaccharides for the therapy of osteosarcoma

Estrogen-functionalized liposomes grafted with glutathione-responsive sheddable chotooligosaccharides for the therapy of osteosarcoma

An estrogen (ES)-functionalized cationic liposomal system was developed and exploited for targeted delivery to osteosarcoma. Natural biocompatible chotooligosaccharides (COS, MW2-5 KDa) were covalently tethered to the liposomal surface through a disulfate bond (-SS-) to confer reduction-responsive C...

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Bibliographic Details
Main Authors: Xuelei Yin, Shuaishuai Feng, Yingying Chi, Jinhu Liu, Kaoxiang Sun, Chuanyou Guo, Zimei Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
estrogen-functionalized
chotooligosaccharides
reduction-sensitivity
targeting
cationic liposomes
osteosarcoma
Online Access:http://dx.doi.org/10.1080/10717544.2018.1458920

Internet

http://dx.doi.org/10.1080/10717544.2018.1458920

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