Immune-Based Therapeutic Strategies for Acute Myeloid Leukemia
The development and design of immune-based strategies have become an increasingly important topic during the last few years in acute myeloid leukemia (AML), based on successful immunotherapies in solid cancer. The spectrum ranges from antibody drug conjugates, immune checkpoint inhibitors blocking p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/1/105 |
| _version_ | 1797499422882398208 |
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| author | Matthias Böhme Sabine Kayser |
| author_facet | Matthias Böhme Sabine Kayser |
| author_sort | Matthias Böhme |
| collection | DOAJ |
| description | The development and design of immune-based strategies have become an increasingly important topic during the last few years in acute myeloid leukemia (AML), based on successful immunotherapies in solid cancer. The spectrum ranges from antibody drug conjugates, immune checkpoint inhibitors blocking programmed cell death protein 1 (PD1), cytotoxic T lymphocyte antigen 4 (CTLA4) or T cell immunoglobulin and mucin domain containing-3 (TIM3), to T-cell based monoclonal and bispecific T-cell engager antibodies, chimeric antigen receptor-T-cell (CAR-T) approaches and leukemia vaccines. Currently, there are many substances in development and multiple phase I/II studies are ongoing. These trials will help us to deepen our understanding of the pathogenesis of AML and facilitate the best immunotherapeutic strategy in AML. We discuss here the mode of action of immune-based therapies and provide an overview of the available data. |
| first_indexed | 2024-03-10T03:47:08Z |
| format | Article |
| id | doaj.art-3a7d5ae22c6e4d63af020aa75b755a19 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:47:08Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3a7d5ae22c6e4d63af020aa75b755a192023-11-23T11:16:07ZengMDPI AGCancers2072-66942021-12-0114110510.3390/cancers14010105Immune-Based Therapeutic Strategies for Acute Myeloid LeukemiaMatthias Böhme0Sabine Kayser1Medical Clinic and Policlinic I, Hematology and Cellular Therapy, University Hospital Leipzig, 04103 Leipzig, GermanyMedical Clinic and Policlinic I, Hematology and Cellular Therapy, University Hospital Leipzig, 04103 Leipzig, GermanyThe development and design of immune-based strategies have become an increasingly important topic during the last few years in acute myeloid leukemia (AML), based on successful immunotherapies in solid cancer. The spectrum ranges from antibody drug conjugates, immune checkpoint inhibitors blocking programmed cell death protein 1 (PD1), cytotoxic T lymphocyte antigen 4 (CTLA4) or T cell immunoglobulin and mucin domain containing-3 (TIM3), to T-cell based monoclonal and bispecific T-cell engager antibodies, chimeric antigen receptor-T-cell (CAR-T) approaches and leukemia vaccines. Currently, there are many substances in development and multiple phase I/II studies are ongoing. These trials will help us to deepen our understanding of the pathogenesis of AML and facilitate the best immunotherapeutic strategy in AML. We discuss here the mode of action of immune-based therapies and provide an overview of the available data.https://www.mdpi.com/2072-6694/14/1/105acute myeloid leukemiaimmunotherapybispecific and dual antigen receptor-targeting antibodieschimeric antigen receptor T-cell therapiesT-cell immune checkpoint inhibitors |
| spellingShingle | Matthias Böhme Sabine Kayser Immune-Based Therapeutic Strategies for Acute Myeloid Leukemia Cancers acute myeloid leukemia immunotherapy bispecific and dual antigen receptor-targeting antibodies chimeric antigen receptor T-cell therapies T-cell immune checkpoint inhibitors |
| title | Immune-Based Therapeutic Strategies for Acute Myeloid Leukemia |
| title_full | Immune-Based Therapeutic Strategies for Acute Myeloid Leukemia |
| title_fullStr | Immune-Based Therapeutic Strategies for Acute Myeloid Leukemia |
| title_full_unstemmed | Immune-Based Therapeutic Strategies for Acute Myeloid Leukemia |
| title_short | Immune-Based Therapeutic Strategies for Acute Myeloid Leukemia |
| title_sort | immune based therapeutic strategies for acute myeloid leukemia |
| topic | acute myeloid leukemia immunotherapy bispecific and dual antigen receptor-targeting antibodies chimeric antigen receptor T-cell therapies T-cell immune checkpoint inhibitors |
| url | https://www.mdpi.com/2072-6694/14/1/105 |
| work_keys_str_mv | AT matthiasbohme immunebasedtherapeuticstrategiesforacutemyeloidleukemia AT sabinekayser immunebasedtherapeuticstrategiesforacutemyeloidleukemia |