Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review
The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity, including anticancer properties. This review aims to analyze the anticancer features of the rhodanines described over the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/12/3750 |
| _version_ | 1797484054490120192 |
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| author | Jacek Szczepański Helena Tuszewska Nazar Trotsko |
| author_facet | Jacek Szczepański Helena Tuszewska Nazar Trotsko |
| author_sort | Jacek Szczepański |
| collection | DOAJ |
| description | The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity, including anticancer properties. This review aims to analyze the anticancer features of the rhodanines described over the last decade in the scientific literature. The structure–activity relationship of rhodanine derivatives, as well as some of the molecular targets, were discussed. The information contained in this review could be of benefit to the design of new, effective small molecules with anticancer potential among rhodanine derivatives or their related heterocycles. |
| first_indexed | 2024-03-09T22:56:00Z |
| format | Article |
| id | doaj.art-3a7f30a0bd284d2f845f67f19b432e33 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T22:56:00Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3a7f30a0bd284d2f845f67f19b432e332023-11-23T18:10:34ZengMDPI AGMolecules1420-30492022-06-012712375010.3390/molecules27123750Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A ReviewJacek Szczepański0Helena Tuszewska1Nazar Trotsko2Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4a Chodźki Street, 20-093 Lublin, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4a Chodźki Street, 20-093 Lublin, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4a Chodźki Street, 20-093 Lublin, PolandThe rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity, including anticancer properties. This review aims to analyze the anticancer features of the rhodanines described over the last decade in the scientific literature. The structure–activity relationship of rhodanine derivatives, as well as some of the molecular targets, were discussed. The information contained in this review could be of benefit to the design of new, effective small molecules with anticancer potential among rhodanine derivatives or their related heterocycles.https://www.mdpi.com/1420-3049/27/12/3750rhodaninesanticancer activitystructure–activity relationshipmolecular targets |
| spellingShingle | Jacek Szczepański Helena Tuszewska Nazar Trotsko Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review Molecules rhodanines anticancer activity structure–activity relationship molecular targets |
| title | Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review |
| title_full | Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review |
| title_fullStr | Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review |
| title_full_unstemmed | Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review |
| title_short | Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review |
| title_sort | anticancer profile of rhodanines structure activity relationship sar and molecular targets a review |
| topic | rhodanines anticancer activity structure–activity relationship molecular targets |
| url | https://www.mdpi.com/1420-3049/27/12/3750 |
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