Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review

The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity, including anticancer properties. This review aims to analyze the anticancer features of the rhodanines described over the...

Full description

Bibliographic Details
Main Authors:	Jacek Szczepański, Helena Tuszewska, Nazar Trotsko
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Molecules
Subjects:	rhodanines anticancer activity structure–activity relationship molecular targets
Online Access:	https://www.mdpi.com/1420-3049/27/12/3750

Similar Items

A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities
by: Seyyed Mojtaba Mousavi, et al.
Published: (2019-12-01)

Synthesis and anticancer activity of novel quinazolinone-based rhodanines
by: Sherihan El-Sayed, et al.
Published: (2017-10-01)

Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR)
by: Ahmad Khairul Daniel bin Ahmad Kamar, et al.
Published: (2022-09-01)

Synthesis and Bioactivity Evaluation of N-Arylsulfonylindole Analogs Bearing a Rhodanine Moiety as Antibacterial Agents
by: Ming-Xia Song, et al.
Published: (2017-06-01)

Synthesis and Characterization of (Z)-5-Arylmethylidene-rhodanines with Photosynthesis-Inhibiting Properties
by: Josef Jampilek, et al.
Published: (2011-06-01)

Novel rhodanine based molecular acceptor for organic solar cells
by: Subianto Surya, et al.
Published: (2017-01-01)

Design, Synthesis, and Antiproliferative Activity of Novel Neocryptolepine–Rhodanine Hybrids
by: Mohamed El-Bahnsawye, et al.
Published: (2022-11-01)

Discovery of Cinnamylidene Derivative of Rhodanine with High Anthelmintic Activity against <i>Rhabditis</i> sp.
by: Waldemar Tejchman, et al.
Published: (2022-03-01)

Synthesis, Crystal Structures, Lipophilic Properties and Antimicrobial Activity of 5-Pyridylmethylidene-3-rhodanine-carboxyalkyl Acids Derivatives
by: Ewa Żesławska, et al.
Published: (2022-06-01)

Green and environmental friendly synthesis of copper (II) and nickel (II) complexes of rhodanine and its antibacterial effectiveness
by: Samuel A. Ajala, et al.
Published: (2022-01-01)

Synthesis of a New [3-(4-Chlorophenyl)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivative
by: Jacek Szczepański, et al.
Published: (2020-07-01)

Design, Synthesis and Biological Assessment of Rhodanine-Linked Benzenesulfonamide Derivatives as Selective and Potent Human Carbonic Anhydrase Inhibitors
by: Baijayantimala Swain, et al.
Published: (2022-11-01)

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies
by: Mohsinul Mulk Bacha, et al.
Published: (2021-04-01)

Green Chemical Synthesis and Biological Evaluation of Novel N-substituted Rhodanine Derivatives as Potential Antifungal Agents
by: Malihe Akhavan, et al.
Published: (2020-02-01)

<i>N</i>-Derivatives of (<i>Z</i>)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1<i>H</i>-indole-2-carboxylates as Antimicrobial Agents—In Silico and In Vitro Evaluation
by: Anthi Petrou, et al.
Published: (2023-01-01)

Synthesis and Antibacterial Activity of Rhodanine-Based Azo Dyes and Their Use as Spectrophotometric Chemosensor for Fe<sup>3+</sup> Ions
by: Dana Akram, et al.
Published: (2020-02-01)

Design, Synthesis and Structure-activity Studies of Rhodanine Derivatives as HIV-1 Integrase Inhibitors
by: Kavya Ramkumar, et al.
Published: (2010-06-01)

Electrochemistry of Rhodanine Derivatives as Model for New Colorimetric and Electrochemical Azulene Sensors for the Detection of Heavy Metal Ions
by: Ovidiu-Teodor Matica, et al.
Published: (2023-03-01)

Rhodanine-Bridged Core-Expanded Naphthalene Diimide Derivatives for n-Type Semiconductors
by: Jiangao Li, et al.
Published: (2020-04-01)

Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology
by: Lili Yan, et al.
Published: (2022-03-01)

Pyrimidine: a review on anticancer activity with key emphasis on SAR
by: Aastha Mahapatra, et al.
Published: (2021-06-01)

Straightforward Regio- and Diastereoselective Synthesis, Molecular Structure, Intermolecular Interactions and Mechanistic Study of Spirooxindole-Engrafted Rhodanine Analogs
by: Assem Barakat, et al.
Published: (2021-11-01)

Molecular Targets of Active Anticancer Compounds Derived from Marine Sources
by: Xiaoping Song, et al.
Published: (2018-05-01)

Electrochemical and spectral studies of rhodanine in view of heavy metals determination
by: Ovidiu Teodor Matica, et al.
Published: (2023-12-01)

Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
by: Kailey A. Wyman, et al.
Published: (2022-09-01)

Pentagalloyl Glucose: A Review of Anticancer Properties, Molecular Targets, Mechanisms of Action, Pharmacokinetics, and Safety Profile
by: Chengli Wen, et al.
Published: (2023-06-01)

Recent Advances in the Application of Cucurbitacins as Anticancer Agents
by: Bartłomiej Zieniuk, et al.
Published: (2023-10-01)

DNA topoisomerases as molecular targets for anticancer drugs
by: Kamila Buzun, et al.
Published: (2020-01-01)

Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones
by: Ignas Grigalius, et al.
Published: (2017-12-01)

Synthesis, Molecular Docking and Biological Evaluation of Glycyrrhizin Analogs as Anticancer Agents Targeting EGFR
by: Yong-An Yang, et al.
Published: (2014-05-01)

Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells
by: Hye-Uk Jung, et al.
Published: (2018-11-01)

2-(Cyclopropylamino)-5-(4-methoxybenzylidene)thiazol-4(5<i>H</i>)-one
by: Ivan Sydorenko, et al.
Published: (2022-10-01)

Direct cellular targets and anticancer mechanisms of the natural product oridonin
by: Jialin Yao, et al.
Published: (2023-03-01)

Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation
by: Naz S, et al.
Published: (2021-04-01)

Steroidal glycoalkaloids from Solanum nigrum target cytoskeletal proteins: an in silico analysis
by: Rumana Ahmad
Published: (2019-01-01)

Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)
by: Ashima Dhiman, et al.
Published: (2022-07-01)

Design, Synthesis, Molecular Docking Study and Biological Evaluation of Novel γ-Carboline Derivatives of Latrepirdine (Dimebon) as Potent Anticancer Agents
by: Ramakrishna Voggu, et al.
Published: (2023-06-01)

The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
by: Dominika Mech, et al.
Published: (2021-10-01)

Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents
by: Li-Jun Wang, et al.
Published: (2015-02-01)

5-[4-(<i>tert</i>-Butyl)cyclohexylidene]-2-thioxothiazolidin-4-one
by: Serhii Holota, et al.
Published: (2021-09-01)