Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old
Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/1/61 |
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| author | Debora Melo van Lent Sarah Egert Steffen Wolfsgruber Luca Kleineidam Leonie Weinhold Holger Wagner-Thelen Birgit Stoffel-Wagner Horst Bickel Birgitt Wiese Siegfried Weyerer Michael Pentzek Frank Jessen Matthias Schmid Wolfgang Maier Martin Scherer Steffi G. Riedel-Heller Alfredo Ramirez Michael Wagner |
| author_facet | Debora Melo van Lent Sarah Egert Steffen Wolfsgruber Luca Kleineidam Leonie Weinhold Holger Wagner-Thelen Birgit Stoffel-Wagner Horst Bickel Birgitt Wiese Siegfried Weyerer Michael Pentzek Frank Jessen Matthias Schmid Wolfgang Maier Martin Scherer Steffi G. Riedel-Heller Alfredo Ramirez Michael Wagner |
| author_sort | Debora Melo van Lent |
| collection | DOAJ |
| description | Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom <i>n</i> = 250 developed all-cause dementia and <i>n</i> = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies. |
| first_indexed | 2024-03-09T03:28:13Z |
| format | Article |
| id | doaj.art-3a8038efd02c4b46aed57131a66d1774 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:28:13Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-3a8038efd02c4b46aed57131a66d17742023-12-03T14:59:19ZengMDPI AGNutrients2072-66432022-12-011516110.3390/nu15010061Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest OldDebora Melo van Lent0Sarah Egert1Steffen Wolfsgruber2Luca Kleineidam3Leonie Weinhold4Holger Wagner-Thelen5Birgit Stoffel-Wagner6Horst Bickel7Birgitt Wiese8Siegfried Weyerer9Michael Pentzek10Frank Jessen11Matthias Schmid12Wolfgang Maier13Martin Scherer14Steffi G. Riedel-Heller15Alfredo Ramirez16Michael Wagner17German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, GermanyInstitute of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, 53115 Bonn, GermanyGerman Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, GermanyDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, GermanyDepartment of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, 53105 Bonn, GermanyDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, GermanyInstitute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53127 Bonn, GermanyDepartment of Psychiatry, Technical University of Munich, 81675 Munich, GermanyWG Medical Statistics and IT-Infrastructure, Institute of General Practice, Hannover Medical School, 30625 Hannover, GermanyCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, GermanyInstitute of General Practice, Medical Faculty, Heinrich-Heine-University, 40227 Dusseldorf, GermanyGerman Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, GermanyGerman Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, GermanyDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, GermanyDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 01403 Leipzig, GermanyGerman Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, GermanyGerman Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, GermanyBackground. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom <i>n</i> = 250 developed all-cause dementia and <i>n</i> = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.https://www.mdpi.com/2072-6643/15/1/61vitaminsvitamin Dbeta-caroteneapolipoprotein E ε4dementiaAlzheimer’s disease dementia |
| spellingShingle | Debora Melo van Lent Sarah Egert Steffen Wolfsgruber Luca Kleineidam Leonie Weinhold Holger Wagner-Thelen Birgit Stoffel-Wagner Horst Bickel Birgitt Wiese Siegfried Weyerer Michael Pentzek Frank Jessen Matthias Schmid Wolfgang Maier Martin Scherer Steffi G. Riedel-Heller Alfredo Ramirez Michael Wagner Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old Nutrients vitamins vitamin D beta-carotene apolipoprotein E ε4 dementia Alzheimer’s disease dementia |
| title | Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old |
| title_full | Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old |
| title_fullStr | Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old |
| title_full_unstemmed | Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old |
| title_short | Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old |
| title_sort | low serum vitamin d status is associated with incident alzheimer s dementia in the oldest old |
| topic | vitamins vitamin D beta-carotene apolipoprotein E ε4 dementia Alzheimer’s disease dementia |
| url | https://www.mdpi.com/2072-6643/15/1/61 |
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